A more accurate and noninvasive look at cancerous tumors
(Medical Xpress) -- Chao Zhou believes his work with combining imaging technologies has the potential to improve surgeries that remove malignant breast tumors.
As many as 40 percent of breast cancer patients now have to undergo a second surgery, because part of the tumor is left behind during the first, says Zhou, an assistant professor of electrical and computer engineering.
By combining two technologiesoptical coherence tomography (OCT) and confocal microscopyZhou says doctors can more precisely pinpoint a tumors location and remove it entirely on the first try.
One advantage of this hybrid approach, he says, is that it allows tissue to be imaged without being damaged or removed from the body. Tissue suspected of being cancerous is now typically removed, sectioned and staineda technique known as histopathologybefore it can be examined.
The combination of OCT and confocal microscopy can also provide information about embryonic forms without requiring samples to be removed from organisms.
Imaging in real time
OCT enables 3-D tissue imaging based on recognition and analysis of the light-scattering patterns caused by internal structures. Confocal microscopy, a form of optical microscopy, produces high-resolution images but cannot penetrate tissue as deeply. Optical coherence microscopy (OCM) combines the two and increases resolution and imaging depth by compiling only coherent light, which is in focus.
The goal of my research is to provide in situ, real-time imaging of tissue microstructures with a resolution approaching that of histopathology, says Zhou, who is affiliated with Lehighs bioengineering program.
Before joining the faculty in June, Zhou was a senior postdoctoral associate at the Massachusetts Institute of Technology, where he pioneered the use of OCT in cancer detection.
He received a Pathway to Independence research award in 2011 from the National Institute of Biomedical Imaging and Bioengineering in the National Institutes of Health.
Until now, says Zhou, doctors have evaluated tumor margin by taking a frozen section or histopathology. These techniques do not provide instant results.
OCT, by contrast, achieves real-time imaging. By combining OCT and OCM, Zhou can alternate between high and low magnifications when viewing the same fresh, unsliced tissue samples. He has been able to identify clusters of cancerous cells within a larger sample based on the tissues appearance under a microscope.
Were also using OCT and OCM to look at developmental biology, Zhou said. In current practice, if you want to examine a developing embryo or animal, you have to sacrifice it and cut it up. Our goal is to be able to image embryonic structures in a less destructive way.
We can image [interior cross-sections of] the systolic and diastolic rhythms of an embryonic flys heart, and compare a normal heart to one with cardio-arrhythmia, Zhou said. Because the heart rhythm is being imaged, it is vital that the organism be living; this can be accomplished with OCT. Zhou plans to extend his imaging of embryonic forms to other organisms.
OCT, when combined with OCM, can get in vivo, 3-D structural and functional images without needing to remove and process tissues, Zhou says. OCT and OCM allow us to lay the foundations for providing real-time information in surgical suites and the pathology lab.
Provided by Lehigh University
- Near-infrared imaging system shows promise as future pancreatic cancer diagnostic tool Aug 17, 2011 | not rated yet | 0
- Girls' verbal skills make them better at arithmetic Feb 23, 2012 | not rated yet | 0
- Seismologist: Christchurch quake location surprising, more large quakes near city unlikely Feb 23, 2011 | not rated yet | 0
- New high-speed 3-D imaging system holds potential for improved cancer screening Aug 01, 2011 | not rated yet | 0
- The embryonic heart: Imaging life as it happens Apr 01, 2010 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
18 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
Breast cancer characterized as "triple negative" carries a poor prognosis, with limited treatment options. In some cases, chemotherapy doesn't kill the cancer cells the way it's supposed to. New research from Western University ...
Cancer 4 hours ago | 5 / 5 (2) | 0
Mayo Clinic researchers have used next generation genomic analysis to determine that some of the more aggressive prostate cancer tumors have similar genetic origins, which may help in predicting cancer progression. The findings ...
Cancer 4 hours ago | not rated yet | 0
Even while being dragged to its destruction inside a cell, a cancer-promoting growth factor receptor fires away, sending signals that thwart the development of tumor-suppressing microRNAs (miRNAs) before it's dissolved, researchers ...
Cancer 5 hours ago | not rated yet | 0 |
Treating pediatric leukemia patients with a liposomal formulation of anthracycline-based chemotherapy at a more intense-than-standard dose during initial treatment may result in high survival rates without causing any added ...
Cancer 9 hours ago | not rated yet | 0
Scientists have uncovered a survival mechanism that occurs in breast cells that have just turned premalignant-cells on the cusp between normalcy and cancers-which may lead to new methods of stopping tumors.
Cancer 10 hours ago | not rated yet | 0 |
(Medical Xpress)—Regulating the distribution of power in neurons is done by a system that makes the national electric grid look simple by comparison. Each neuron has several thousand mitochondria confined ...
4 hours ago | 4.8 / 5 (5) | 0 |
Teams of highly respected Alzheimer's researchers failed to replicate what appeared to be breakthrough results for the treatment of this brain disease when they were published last year in the journal Science.
8 hours ago | 5 / 5 (1) | 2 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
8 hours ago | 5 / 5 (2) | 0 |
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
10 hours ago | 4.9 / 5 (7) | 0 |
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center ...
8 hours ago | not rated yet | 0 |
Ethnic background plays a surprisingly large role in how diabetes develops on a cellular level, according to two new studies led by researchers at the Stanford University School of Medicine.
6 hours ago | not rated yet | 0 |