Cutting calories might help you live longer, but not without increased physical activity
Dietary restriction can slow age-related diseases and extend the lifespan of all species tested to date. Understanding this phenomenon might help people live longer, preferably without having to drastically limit calories. Now, investigators reporting in the July 3 issue of the Cell Press journal Cell Metabolism have found that in flies, dietary restriction causes enhanced fat metabolism in the muscle and increased physical activity, both of which are critical for extending lifespan. The findings suggest that dietary restriction may cause changes in muscle that can lead to a more active and longer life.
In fruit flies, restriction of yeast, the major source of protein in the fly diet, robustly prolongs life. To see what specific effects dietary restriction has on the body, investigators cut yeast from flies' diets and then conducted various biochemical tests. They found that following dietary restriction, the flies became more physically active, and this increased physical activity was required for extending the flies' lifespan. Flies on a restricted diet that could not move did not live longer.
The researchers also found that this increased physical activity was due to a shift in the flies' metabolism so that they increased both fat synthesis and breakdown. Blocking fat synthesis specifically in the muscle tissue negated the lifespan-extending effects of dietary restriction.
These results suggest that simply restricting nutrients without increasing physical activity may not be beneficial in humans. "Ours is the first study to suggest that for dietary restriction to enhance lifespan, you need increased fat turnover in the muscle and an associated increase in physical activity. Furthermore, it also suggests that dietary changes may enhance motivation to exercise and help derive maximal benefits of exercise," says senior author Dr. Pankaj Kapahi, from the Buck Institute for Research on Aging.
The researchers also found that overexpression of the hormone AKH, the fly equivalent of glucagon, enhanced flies' fat metabolism, boosted their activity, and extended their lifespan even though their diet was unrestricted.
"Our data suggest that dietary restriction may induce changes in muscle similar to those observed under endurance exercise and that molecules like AKH that enhance fat breakdown could serve as potential dietary restriction mimetics," the authors wrote. This indicates that medical interventions that enhance fat metabolism in muscle might have the potential to prolong life.
More information: Katewa et al.: Intra-myocellular fatty acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metabolism - July 3, 2012 print issue print issue, DOI:10.1016/j.cmet.2012.06.005
Journal reference: Cell Metabolism
Provided by Cell Press
- Physical activity needed in order to reap benefits of dietary restriction Jul 02, 2012 | not rated yet | 0
- 'Anti-Atkins' low protein diet extends lifespan in flies Oct 01, 2009 | not rated yet | 0
- Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction May 22, 2009 | not rated yet | 0
- Biologists link calorie restriction, endocrine function in worm longevity Jun 18, 2007 | not rated yet | 0
- Scientists find molecular trigger that helps prevent aging and disease Nov 18, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
In their quest to learn more about the variability of cells between and within tissues, biomedical scientists have devised tools capable of simultaneously measuring dozens of characteristics of individual ...
Medical research 1 hour ago | 5 / 5 (1) | 0 |
In 2008 researchers from the University of Southern Denmark showed that the drug thioridazine, which has previously been used to treat schizophrenia, is also a powerful weapon against antibiotic-resistant bacteria such as ...
Medical research May 17, 2013 | 3.7 / 5 (3) | 0 |
Scientists investigating the interaction of a group of proteins in the brain responsible for protecting nerve cells from damage have identified a new target that could increase cell survival.
Medical research May 17, 2013 | 5 / 5 (1) | 0
New findings by researchers carrying out experiments at the U.S. Department of Energy Office of Science's Advanced Photon Source (APS) help explain why some drugs that interact with two kinds of human serotonin ...
Medical research May 17, 2013 | 4 / 5 (1) | 0 |
Researchers at the University of Wisconsin have identified a potential new risk factor for obstructive sleep apnea: asthma. Using data from the National Institutes of Health (Heart, Lung, and Blood Institute)-funded Wisconsin ...
41 minutes ago | not rated yet | 0 |
A new study looking at sleep-disordered breathing (SDB) and markers for Alzheimer's disease (AD) risk in cerebrospinal fluid (CSF) and neuroimaging adds to the growing body of research linking the two.
51 minutes ago | not rated yet | 0 |
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
41 minutes ago | not rated yet | 0
Scientists at Johns Hopkins have turned their view of osteoarthritis (OA) inside out. Literally. Instead of seeing the painful degenerative disease as a problem primarily of the cartilage that cushions joints, ...
1 hour ago | 5 / 5 (1) | 0 |
The hunt for an HIV vaccine has gobbled up $8 billion in the past decade, and the failure of the most recent efficacy trial has delivered yet another setback to 26 years of efforts.
5 hours ago | not rated yet | 0
The devastating effect of Alzheimer's disease on bilingual people has been thrown into focus in Canada, where the sudden loss of a second language can leave sufferers feeling like strangers in their own country.
3 hours ago | not rated yet | 0