Children continue to be underrepresented in drug trials

Children continue to be underrepresented in drug trials
Even for conditions with a high pediatric disease burden, only a small proportion of clinical drug trials study pediatric patients, according to research published online July 23 in Pediatrics.

(HealthDay) -- Even for conditions with a high pediatric disease burden, only a small proportion of clinical drug trials study pediatric patients, according to research published online July 23 in Pediatrics.

Florence T. Bourgeois, M.D., M.P.H., from Harvard University in Boston, and colleagues identified all registered in ClinicalTrials.gov with start dates between 2006 and 2011 and tracked the resulting publications for conditions with a high burden of pediatric disease.

The researchers found that, for the selected conditions, 59.9 percent of the disease burden was seen in children, but only 292 of 2,440 trials (12.0 percent) were for (P < 0.001). Trials conducted without industry funding were significantly more common in pediatric populations compared with adults (58.6 versus 35.0 percent). Pediatric randomized trials were significantly less likely to examine safety outcomes compared with adult randomized trials (10.1 versus 16.9 percent) and had a modestly higher probability of publication in the examined time frame (32.8 versus 23.2 percent; P = 0.04).

"There is substantial between pediatric burden of disease and the amount of clinical trial research devoted to pediatric populations," the authors write. "This may be related in part to trial funding, with relying primarily on government and nonprofit organizations."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Children neglected in clinical drug trials

date Apr 29, 2012

Although children are more likely than adults to suffer from many diseases, few clinical trials are being conducted to test drugs in pediatric patients, according to a study to be presented Saturday, April 28, at the Pediatric ...

Positive outcome no more likely in industry-funded trials

date Jul 05, 2012

(HealthDay) -- Industry-sponsored clinical trials of rheumatoid arthritis drugs are no more likely to report positive outcomes than trials funded by other means, and in many cases use better methodology, according ...

Recommended for you

Cribs are for sleeping, car seats are for traveling

date Apr 24, 2015

Sleep-related deaths are the most common cause of death for infants 1-12 months of age. The American Academy of Pediatrics recommends that infants sleep on their back on a firm mattress, without loose bedding. However, many ...

One child in five still not vaccinated: WHO

date Apr 22, 2015

One-fifth of the world's children are still not receiving routine life-saving vaccinations and efforts to ensure global immunisation coverage remain "far off track," the World Health Organization said Wednesday.

Reducing school bus pollution improves children's health

date Apr 22, 2015

Use of clean fuels and updated pollution control measures in the school buses 25 million children ride every day could result in 14 million fewer absences from school a year, based on a study by the University ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.