Good long-term limb salvage for diabetic foot patients

Good long-term limb salvage for diabetic foot patients
For patients with diabetic foot ulcers, long-term limb salvage is favorable; however, long-term survival remains poor, particularly for those with peripheral artery disease or chronic renal insufficiency, according to a study published online July 18 in Diabetes Care.

(HealthDay) -- For patients with diabetic foot ulcers (DFUs), long-term limb salvage is favorable; however, long-term survival remains poor, particularly for those with peripheral artery disease (PAD) or chronic renal insufficiency, according to a study published online July 18 in Diabetes Care.

To assess the correlation between patient and limb survival in patients with DFUs, Stephan Morbach, M.D., of the Marienkrankenhaus in Soest, Germany, and colleagues conducted a prospective study involving 247 consecutive patients with DFUs and without previous major amputation. Participants (mean age 68.8 years; 58.7 percent male; 55.5 with PAD) presented between June 1998 and December 1999 and were followed until May 2011.

The researchers found that 15.4 percent of patients experienced a first major amputation during follow-up. PAD was present in 37 of these 38 patients at study inclusion, and 51.4 percent had severe PAD. Significant predictors for the first major amputation included age (hazard ratio [HR], 1.05 per year), dialysis (HR, 3.51), and PAD (HR, 35.34). At years one, three, five, and 10, cumulative were 15.4, 33.1, 45.8, and 70.4 percent, respectively. Death in these patients was significantly predicted by increasing age (HR, 1.08 per year), (HR, 1.83), dialysis (HR, 6.43), and PAD (HR, 1.44).

"In conclusion, data from this long-term study suggest strongly that limb preservation today is the rule rather than the exception, even in high-risk patients with diabetes," the authors write. "Long-term survival remains poor, however, probably because of myriad comorbid conditions for patients whose first presentation to an interdisciplinary clinic is with a diabetic foot ulcer."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Depression linked to greater risk of peripheral artery disease

Apr 20, 2012

Depression may be associated with an increased risk of arterial narrowing in the legs and pelvis, a condition known as peripheral artery disease (PAD), according to research presented at the American Heart Association's Arteriosclerosis, ...

Bortezomib ups response, survival in multiple myeloma

Jul 23, 2012

(HealthDay) -- For patients with newly diagnosed multiple myeloma (MM), induction treatment with a combination of bortezomib, doxorubicin, and dexamethasone (PAD) followed by bortezomib maintenance therapy ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.