Researchers identify link between kidney removal and erectile dysfunction

Researchers at the University of California, San Diego School of Medicine have identified a link between patients who undergo total nephrectomy - complete kidney removal - and erectile dysfunction. Results from the multi-center study were recently published online in the British Journal of Urology International.

"This is the first study in medical literature to suggest that surgery for can negatively impact erectile function while partial kidney removal can protect sexual function," said Ithaar Derweesh, MD, senior author, associate professor of surgery, UC San Diego School of Medicine and urologic surgeon at UC San Diego Health System.

The retrospective study evaluated two cohorts of men, totaling 432 patients, who underwent surgery for . One group underwent complete removal of the kidney while the other had kidney-sparing surgery. Sexual function was accessed pre- and post-operatively with a sexual health questionnaire known as the International Index of Erectile Function.

"What we are seeing is a dramatic yet delayed effect. Approximately six years after surgery, patients who had a total nephrectomy were 3.5 times more likely to develop erectile dysfunction compared to those who had kidney reconstruction," said Derweesh.

"The primary argument for kidney-sparing surgery over total kidney removal has been to preserve the kidney filtration function. However, we are also beginning to understand that total kidney removal may also increase the risk of and significantly decrease quality of life," said lead author Ryan Kopp, MD, chief resident, Division of Urology, UC San Diego School of Medicine.

Derweesh added that this is the latest in a series of studies that point to the wisdom of saving the kidney in appropriate patients. Prior research led by Derweesh also shows that can reduce the risk of osteoporosis and chronic kidney insufficiency which can lead to cardiac events and metabolic disturbances. Further investigation is needed to prevent erectile dysfunction in patients and to predict its potential occurrence.

Related Stories

Kidney-preserving surgery saves bone health

Aug 05, 2011

Researchers at the University of California, San Diego School of Medicine have shed new light on how surgery impacts both chronic kidney disease and bone health, particularly in women. For the first time, their findings point ...

How less can be more when treating some kidney cancers

Jan 09, 2008

A new Mayo Clinic study suggests that removing the entire kidney from younger patients with small kidney tumors may lead to decreased overall survival compared with an operation that removes the tumor but leaves the kidney ...

Recommended for you

NY and NJ say they will require Ebola quarantines

2 hours ago

The governors of New Jersey and New York on Friday ordered a mandatory, 21-day quarantine for all doctors and other arriving travelers who have had contact with Ebola victims in West Africa.

WHO: Mali case may have infected many people

6 hours ago

The World Health Organization says a toddler who brought Ebola to Mali was bleeding from her nose during her journey on public transport and may have infected many people.

Two US nurses are declared cured of Ebola

7 hours ago

Two American nurses were declared cured of Ebola on Friday, and one was healthy enough to leave the hospital and meet President Barack Obama for a hug.

User comments