Mechanistic insights into Old English plants

Jasminum humile inhibits calcineurin. Credit: Geoffrey Kite

Often lacking in natural product drug discovery are ‘mechanistic insights’; that is, insights into the events at the molecular level that are behind any effects that plant compounds have on cells or organisms. With this in mind, Tom Prescott screened 250 Old English plants from the Queen’s Garden at Kew, to search for compounds that inhibit the human enzyme calcineurin. The results have been published in the Journal of Ethnopharmacology.

Calcineurin plays an important role in regulating human T-cell activation in the immune response, and inhibition of this process can be beneficial in certain auto-immune diseases.

Nepeta cataria and Teucrium chamaedrys showed initial promise but the compounds responsible (phenylpropanoid glycosides) were only strongly active against the basal, un-activated form of the enzyme.

Jasminum humile was found to be more promising as the ethanol extract inhibited both isolated human calcineurin enzyme and calcineurin-dependent gene expression in yeast cells. This demonstrated that plants do indeed produce compounds that directly inhibit .

More information: Prescott, T. A. K., et al. (2011). Direct inhibition of calcineurin by caffeoyl phenylethanoid glycosides from Teucrium chamaedrys and Nepeta cataria. Journal of Ethnopharmacology 137: 1306–1310.

Prescott, T. A. K., et al. (2012). Inhibition of human calcineurin and yeast calcineurin-dependent gene expression by Jasminum humile leaf and root extracts. Journal of Ethnopharmacology 140: 293-297.

add to favorites email to friend print save as pdf

Related Stories

Time to stop giving toxic drugs to kidney transplant patients?

Sep 22, 2011

Patients who receive kidney transplants must take lifelong medications that, while preventing organ rejection, can also compromise other aspects of health. Immunosuppresive drugs called calcineurin inhibitors protect transplanted ...

Recommended for you

A new tool in drug overdose prevention

21 hours ago

The Center for Disease Control reported earlier this month that the heroin overdose death rate across 28 states it surveyed doubled between 2010 and 2012. This sharp increase and the chilling statistics that say more than 11 ...

Nasal spray treats heroin overdose

Oct 28, 2014

"Every year, drug overdoses are responsible for roughly 1000 ambulance calls in Oslo," says Arne Skulberg, an anaesthesiologist, a PhD candidate at NTNU and the 2014 winner of Norway's Researcher Grand Prix ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.