Molecular causes for life-threatening fungal infections in case of sepsis unravelled

July 27, 2012
Molecular causes for life-threatening fungal infections in case of sepsis unravelled

(Medical Xpress) -- Pathogenic fungi cause infections with a high mortality rate in patients with weakened immune systems. At Karl Kuchler’s CD Laboratory at the MedUni Vienna, the molecular causes of the life-threatening inflammatory reactions that are triggered by fungal infections are being deciphered.

With infectious diseases, it is often not the pathogen itself, but rather an excessive inflammatory immune response (= sepsis) that contributes to the patient’s death, for instance as a result of organ damage. On intensive care units, sepsis is the second-most common cause of death worldwide. In patients with a severely compromised specially, life-threatening candida fungal infections represent a high risk of sepsis.

The working group led by Karl Kuchler in the Christian Doppler Laboratory for Infection Biology (Max. F. Perutz Laboratories at the Vienna Biocenter Campus) has now deciphered the molecular causes of life-threatening inflammatory reactions that are triggered by fungal infections: two highly aggressive types of phagocytes in the immune system (neutrophils and inflammatory monocytes), which however also have a high potential for collateral destruction, mediate the inflammatory reaction during an infection with candida. Certain interferons, the messenger substances used by the immune system, which are excreted during , stimulate the influx of immune cell types to infected organs and lead to sepsis.

Strategy: block the immune response

“We have been able to demonstrate for the first time that the targeted blockade of this immune response with inflammation-inhibiting drugs can significantly reduce candida sepsis and therefore mortality,” says Karl Kuchler, who used an anti-inflammatory substance in the study that is also used as an active ingredient in the treatment of type 2 diabetes – namely pioglitazone.

When this medication was administered, the number and activity of neutrophils and inflammatory monocytes in the mouse model were specifically reduced, and the survival rate was increased for invasive candida infections. “The targeted blockade of excessive immune responses could therefore provide new therapeutic approaches to increase the chances of recovery from life-threatening fungal sepsis,” says Kuchler.

Infectious diseases are the world’s number 1 cause of death, with pathogenic fungi being responsible for extremely dangerous infections. Worldwide, more than € 6 billion are spent each year on anti-fungal medications, and the total costs of the medical treatment of infectious diseases caused by is estimated at hundreds of billions of Euros. 

Explore further: Researchers find quick candida test

More information:Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections”, Olivia Majer, et al. PLoS Pathog. 2012 June.

Related Stories

Researchers find quick candida test

August 2, 2011

A team led by a Massey University researcher has developed a diagnostic tool that could save the lives of some of the 60 people estimated to die each year in New Zealand from the fungal infection candidemia – and thousands ...

Late-stage sepsis suppresses immune system

January 11, 2012

(Medical Xpress) -- Patients who die from sepsis are likely to have had suppressed immune systems that left them unable to fight infections, researchers at Washington University School of Medicine in St. Louis have shown.

Recommended for you

Zika in fetal brain tissue responds to a popular antibiotic

November 30, 2016

Working in the lab, UC San Francisco researchers have identified fetal brain tissue cells that are targeted by the Zika virus and determined that azithromycin, a common antibiotic regarded as safe for use during pregnancy, ...

Zika and glaucoma linked for first time in new study

November 30, 2016

A team of researchers in Brazil and at the Yale School of Public Health has published the first report demonstrating that the Zika virus can cause glaucoma in infants who were exposed to the virus during gestation.

Flu forecasts successful on neighborhood level

November 30, 2016

Scientists at Columbia University's Mailman School of Public Health developed a computer model to predict the onset, duration, and magnitude of influenza outbreaks for New York City boroughs and neighborhoods. They found ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.