First Polypill trial in people selected on age alone (50 and over) shows substantial health benefit
Results of a randomised trial carried out by academics at Queen Mary, University of London and published today in PLoS One  show that a four-component Polypill given to people aged 50 and over to reduce their risk of heart attack and stroke, the most common causes of death worldwide, achieved large reductions in blood cholesterol and blood pressure, the main causes of these two diseases.
The research was conducted at the Wolfson Institute of Preventive Medicine at Barts and The London School of Medicine & Dentistry, part of Queen Mary, University of London. The results observed in the trials had been accurately predicted in an earlier paper published in the British Medical Journal before any Polypill had been made .
The Polypill, a tri-layered tablet, contains three blood pressure lowering medicines and a statin for lowering cholesterol. This was given to people without a history of cardiovascular disease aged 50 or more. They experienced a 12 percent reduction in blood pressure and a 39 percent reduction in LDL cholesterol (the 'harmful' cholesterol), achieving levels typical of people aged 20 years.
"The health implications of our results are large. If people took the Polypill from age 50, an estimated 28 percent would benefit by avoiding or delaying a heart attack or stroke during their lifetime; on average, those who benefit would gain 11 years of life without a heart attack or stroke," said Dr David Wald, principal investigator of the trial.
The study was a randomised placebo-controlled cross-over trial in which each person took the Polypill for three months and a placebo (dummy pill) for three months, in random sequence. The cross-over design and the high adherence to treatment among the participants meant that the trial produced highly accurate and reliable results with each person acting as his or her own control.
This is the first trial in people selected on the basis of age alone without the need for a medical examination or tests setting the scene for the prevention of first heart attacks and strokes in the general population without requiring a medical examination or special tests.
Dr Wald said: "Our trial shows that the predicted effects of the Polypill can be achieved in practice. The expected impact on preventing what is now the world's leading cause of death is large about a two-thirds reduction in heart attacks and strokes."
Professor David Taylor, Professor of Pharmaceutical and Public Health Policy at University College London, and a participant in the trial, said: "The Polypill concept is a major public health advance. This study shows that it works. The Polypill should be made generally available as a matter of urgency. I welcome the opportunity to substantially cut my risk of having a stroke or heart attack without the disempowering fuss and bother usually required to obtain preventive medicines."
The inventor of the Polypill, Professor Sir Nicholas Wald, Director of the Wolfson Institute of Preventive Medicine at Queen Mary, University of London, said: "We now need public, professional and regulatory support to make the Polypill available without delay; the net benefits are too large to ignore even if only 50 percent of people aged 50 or more took the Polypill, about 94,000 heart attacks and stroke would be prevented each year in the UK."
More information:  "Randomized Polypill crossover trial in people aged 50 and over" by David Wald, Joan Morris, and Nicholas Wald. Published in PLoS One on Wednesday July 18 at: www.plosone.org/ar… pone.0041297
 Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003;326:1419-24
Provided by Queen Mary, University of London
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