New technology represents next-generation tool for detecting substandard and counterfeit medicines
A new platform for detecting substandard and counterfeit medicines using microfluidics has been recognized with a grant from Saving Lives at Birth's "Grand Challenge through Development." Dubbed PharmaCheck, the technology is a portable, field-based tool for assessing the quality of medicines in developing countries with increased accuracy, sensitivity and reliability.
Through the Challenge, the U.S. Agency for International Development (USAID), Bill & Melinda Gates Foundation, Grand Challenges Canada and the U.K. Department for International Development sought groundbreaking prevention and treatment approaches for pregnant women and newborns in poor, hard-to-reach communities in developing countries. Substandard and counterfeit medicines for diseases including malaria, tuberculosis and HIV/AIDS pose a dire public health threat to patients in developing countries, in particular children and pregnant women. Such medicines can exacerbate the course of these diseases, even leading to death, as well as contribute to the growth of drug-resistant disease parasitesthreatening the viability of treatments for patients worldwide.
Developed by Boston University in collaboration with the Promoting the Quality of Medicines (PQM) program, which is supported by USAID and implemented by the U.S. Pharmacopeial Convention (USP), PharmaCheck has reached the proof of concept stagedemonstrating a quantitation linear relationship for analysis of an antimalarial medicine of interest on a microfluidic chip. The technology addresses shortcomings of current field-based, portable quality control laboratories currently in use throughout the developing worldincluding the inability to precisely and accurately measure the percentage of the active pharmaceutical ingredient or other important quality attributes of medicines. These are key to determining whether a medicine is of poor quality or not. Furthermore, the technology is expected to greatly reduce the need for confirmation of field-tested results at fully equipped quality control laboratories.
"This technology promises to be groundbreaking in the fight against substandard and counterfeit medicines," said Mr. Anthony Boni, Pharmaceutical Management Specialist for USAID's Global Health Bureau, Office of Health, Infectious Diseases and Nutrition/Health Systems Division. "Inexpensive, easy-to-use and effective, we expect that PharmaCheck will represent a paradigm shift in combating the scourge of poor-quality medicines. One of the most exciting elements is the ability to potentially deploy this technology at point-of-use, with an ultimate vision of healthcare facilities, clinics and hospitals using the technology to verify the quality of the medicines they receive."
"This technology is an important breakthrough as we strive to help ensure the quality, safety and efficacy of medicines essential to treating patients suffering from malaria, tuberculosis and HIV/AIDS in developing countries around the world," said Dr. Patrick Lukulay, Vice President of Global Health Impact Programs for USP and Director of the PQM Program. "This will be a very powerful tool with broad application and impact. We are very pleased to be partnering with Boston University in advancing this technology."
With this new grant, Boston University, led by Dr. Muhammad Zaman, will be able to accelerate development of PharmaCheck and the deployment of a finished product.
Provided by US Pharmacopeia
- New database to help track quality of medicines in global markets Apr 05, 2011 | not rated yet | 0
- Substandard and counterfeit antimalarial drugs discovered in Ghana Nov 08, 2010 | not rated yet | 0
- Fake malaria drugs threaten crisis in Africa Jan 17, 2012 | not rated yet | 0
- New guidelines will help detect and study counterfeit medicines Mar 24, 2009 | not rated yet | 0
- More AIDS patients may get cheaper drugs Jul 12, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
6 hours ago Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
An independent panel of experts on Wednesday recommended US approval of a new Merck sleeping pill called suvorexant, but expressed concerns over the highest dosage and risks of drowsy daytime driving.
Medications 15 hours ago | not rated yet | 0
GlaxoSmithKline PLC says it's starting an unusual collaboration with the U.S. government to develop several antibiotics for both bioterrorism threats and bacterial infections resistant to current medicines.
Medications 17 hours ago | not rated yet | 0
The new 13-valent pneumococcal conjugate vaccine (PCV13) appears to be as safe as the previous version used prior to 2010, the 7-valent pneumococcal conjugate vaccine (PCV7), according to a Kaiser Permanente study published ...
Medications 22 hours ago | not rated yet | 0
The University of Gothenburg Vaccine Research Institute (GUVAX) announces successful results in a placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine.
Medications May 22, 2013 | not rated yet | 0
For the first time, physicists from the Max Planck Institute for Extraterrestrial Physics (MPE), biologists and physicians demonstrated the synergistic effect of cold atmospheric plasma - a partly ionized ...
1 hour ago | 5 / 5 (1) | 0 |
(Medical Xpress)—Scientists from the Joint Center for Structural Genomics (JCSG) at SLAC National Accelerator Laboratory have determined the 3-D structure of the chemically active part of an enzyme involved ...
43 minutes ago | not rated yet | 0 |
(Medical Xpress)—Research by U of T Mississauga psychology professor Glenn Schellenberg reveals that two key personality traits – openness-to-experience and conscientiousness—predict better than IQ ...
23 minutes ago | not rated yet | 0 |
Professor Michael Jennings, Deputy Director of the Institute for Glycomics at Griffith University, was part of an international team that discovered the previously unknown pathway of how the bacterium colonizes people.
1 minute ago | not rated yet | 0 |
Aggressive forms of bladder cancer involve the protein PODXL – a discovery that could hold the key to improved treatment, according to researchers at Lund University, Uppsala University and KTH in Sweden.
33 minutes ago | 5 / 5 (1) | 0
A study from the June issue of Anesthesiology found feedback from the front region of the brain is a crucial building block for consciousness and that its disruption is associated with unconsciousness when the anesthetics ketami ...
1 hour ago | not rated yet | 0