UVC light kills wound bacteria

July 23, 2012

Ultraviolet (UVC) light can eradicate wound-infecting bacteria on mice increasing both survival and healing rates, according to a paper in the July 2012 issue of Antimicrobial Agents and Chemotherapy. The light did not damage the animals' skin or delay wound healing, says principal investigator Michael R. Hamblin, of the Massachusetts General Hospital, and the Harvard Medical School, Boston, MA.

range from the superficial, to the life threatening, which are rare except among . However, "…these infections are becoming worrisome due to bacterial resistance to conventional antibiotics," the researchers write.

Unlike with antibiotics, bacteria probably cannot develop complete resistance to UVC light, "although it is possible that variants with enhanced DNA repair systems may emerge," the investigators note, adding that only four times more radiation would be needed to decimate Deinococcus radiodurans, a species that is famous for its radiation resistance, than in the case of E. coli.

In the study, the investigators infected the mice with bioluminescent strains of gram-negative Pseudomonas aeruginosa, and Staphylococcus aureus, the former "noted for its invasive properties in mouse wound models," according to the report. The dimming of the bioluminescence—down to near zero—indicated the fate of the infective bacteria. The mice were exposed to UVC light 30 minutes after inoculation.

For both bacteria UVC treatment reduced bacterial contamination of wounds by 10-fold compared to untreated mice. In addition, treatment increased the survival rate of mice infected with P. aeruginosa and the rate in mice infected with S. aureus.

"These results suggested that UVC light may be used for the prophylaxis of cutaneous wound infections," write the researchers.

More information: T. Dai, B. Garcia, C.K. Murray, M.S. Vrahas, and M.R. Hamblin, 2012. UVC light prophylaxis for cutaneous wound infections in mice. Antim. Agents Chemother. 56:3841-3848.

Related Stories

Recommended for you

Fighting the aging process at a cellular level

September 22, 2016

It was about 400 BC when Hippocrates astutely observed that gluttony and early death seemed to go hand in hand. Too much food appeared to 'extinguish' life in much the same way as putting too much wood on a fire smothers ...

Tattoo therapy could ease chronic disease

September 22, 2016

A temporary tattoo to help control a chronic disease might someday be possible, according to scientists at Baylor College of Medicine who tested antioxidant nanoparticles created at Rice University.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.