The world's number of IVF and ICSI babies has now reached a calculated total of 5 million

The number of babies born as a result of assisted reproduction technologies (ART) has reached an estimated total of 5 million since the world's first, Louise Brown, was born in July 1978. The figures will be presented this week at the 28th annual meeting of ESHRE (European Society of Human Reproduction and Embryology), which begins today, 1st July, in Istanbul, Turkey.

The calculation was made for a presentation at the congress from ICMART (International Committee for Monitoring ) and was based on the number of and ICSI treatment cycles recorded worldwide up to 2008 with estimations added for the following three years. The cumulative total of births was put at 4.6 million last year, and this year has now reached an approximate total of 5 million.

Commenting on this remarkable milestone, Dr David Adamson, from Fertility Physicians of Northern California, USA, and Chairman of ICMART, said: "It means that this technology has been highly successful in treating infertile patients. Millions of families with children have been created, thereby reducing the burden of infertility.

"The technology has improved greatly over the years to increase . The babies are as healthy as those from other infertile patients who conceive spontaneously. The technology is available globally in many different cultures. The major barriers to access are economic, and societal in some situations. With these accomplishments as a technology, and with recognition of Professor as a Nobel Laureate, IVF is firmly established now in the mainstream of medicine."

Other ICMART data indicate that around 1.5 million ART cycles are now performed globally each year, producing around 350,000 babies. This number continues to rise. The two most active countries of the world are the USA and Japan, but the most active region by far is Europe.

The picture in Europe

The latest European data to be presented at the ESHRE congress are for 2009, and show that demand for treatment - as expressed in treatment cycles performed in European countries - continues to grow, from 532,260 in 2008 to 537,287 in 2009.

The average availability of ART in Europe is close to 1000 cycles/million inhabitants, but this figure varies greatly between countries and is largely dependent on local state funding policies. Availability in Europe is greater than in the USA but less than in Australia.

Dr Anna Pia Ferraretti, chairman of ESHRE's IVF Monitoring Consortium, said that the global need for ART is estimated to be at least 1500 cycles/million population per year, a figure only seen in Denmark (2726 cycles/million), Belgium (2562 cycles), Czech Republic (1851 cycles), Slovenia (1840 cycles), Sweden (1800 cycles), Finland (1701 cycles) and Norway (1780 cycles). Countries with much lower availability included Austria (747 cycles/million), Germany (830 cycles), Italy (863 cycles) and UK (879 cycles).

Success rates from a single "fresh" treatment cycle of IVF and ICSI - as first indicated in data for 2008 presented last year - seem to have stabilised, at around 32% pregnancy rate per embryo transfer (and 28% per aspiration). Dr Ferraretti said there had been a notable decline in the number of embryos transferred, with cumulative delivery rates, which include the transfer of frozen/thawed embryos from the same stimulation cycle, now representing "the best indicator of outcome". By using this endpoint, she explained, delivery rates can increase substantially while maintaining a very low multiple rate.

On this contentious question of multiple pregnancies, Dr Ferraretti said: "The overall trend in Europe of transferring fewer embryos continues. We found in 2009 that, compared with previous years, fewer three-embryo transfers and more single embryo transfers were performed. As a result of this trend, ART triplets have fallen below 1%, and, for the first time, the twin delivery rate was below 20% (19.6%)."

add to favorites email to friend print save as pdf

Related Stories

ICSI or IVF: Babies born from frozen embryos do just as well

Jun 29, 2009

Analysis of the longest running ICSI programme in the United States has found reassuring evidence that babies born from frozen embryos fertilised via ICSI (intracytoplasmic sperm injection) do just as well as those born from ...

Recommended for you

UK proposes rules for embryos made from 3 people

Dec 17, 2014

(AP)—New rules proposed in Britain would make it the first country to allow embryos to be made from the DNA of three people in order to prevent mothers from passing on potentially fatal genetic diseases to their babies.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.