Five CSF markers differentiate dementia, parkinsonism

Five CSF markers differentiate dementia, parkinsonism
Levels of five different cerebrospinal fluid biomarkers are able to improve differentiation between common dementia and parkinsonian disorders, according to a study published online Aug. 27 in the Archives of Neurology.

(HealthDay)—Levels of five different cerebrospinal fluid (CSF) biomarkers are able to improve differentiation between common dementia and parkinsonian disorders, according to a study published online Aug. 27 in the Archives of Neurology.

Sara Hall, M.D., from Lund University in Sweden, and colleagues assessed the ability of five CSF biomarkers to differentiate between 453 CSF samples from healthy controls and patients with Parkinson's disease (PD), PD with dementia (PDD), dementia with Lewy bodies (DLB), Alzheimer's disease (AD), progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or corticobasal degeneration (CBD).

The researchers found that CSF levels of α-synuclein were increased in patients with AD and decreased in patients with PD, PDD, DLB, and MSA. Decreased levels of β-amyloid 1-42 were seen in DLB. In AD, β-amyloid 1-42 levels were further decreased and CSF levels of total tau and hyperphosphorylated tau were increased. These biomarkers were able to distinguish AD from DLB and PDD with an area under the curve of 0.90, with the main contribution from α-synuclein and total tau. In atypical parkinsonian disorders (PSP, MSA, and CBD), CSF levels of neurofilament light chain were increased, and that level alone could be used to differentiate PD from atypical parkinsonian disorders with an area under the curve of 0.93.

"Together with earlier published data, our results indicate that these five CSF might have clinical value in the differential diagnosis of and/or parkinsonism," Hall and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Recommended for you

Finding the body clock's molecular reset button

date 1 hour ago

An international team of scientists has discovered what amounts to a molecular reset button for our internal body clock. Their findings reveal a potential target to treat a range of disorders, from sleep ...

A 'GPS' to navigate the brain's neuronal networks

date 1 hour ago

In new research published today by Nature Methods, scientists from the Hebrew University of Jerusalem and Harvard University have announced a "Neuronal Positioning System" (NPS) that maps the circuitry of the ...

Neurons constantly rewrite their DNA

date 2 hours ago

Johns Hopkins scientists have discovered that neurons are risk takers: They use minor "DNA surgeries" to toggle their activity levels all day, every day. Since these activity levels are important in learning, ...

Hate to diet? It's how we are wired

date 2 hours ago

If you're finding it difficult to stick to a weight-loss diet, scientists at the Howard Hughes Medical Institute's Janelia Research Campus say you can likely blame hunger-sensitive cells in your brain known ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.