Levels of etonogestrel lower in obese women after implant

Levels of etonogestrel lower in obese women after implant
Obese women who receive a contraceptive implant have lower drug levels in the six months following implant insertion compared with normal-weight women, according to a study published in the August issue of the American Journal of Obstetrics & Gynecology.

(HealthDay) -- Obese women who receive a contraceptive implant have lower drug levels in the six months following implant insertion compared with normal-weight women, according to a study published in the August issue of the American Journal of Obstetrics & Gynecology.

Sara Mornar, D.O., from the University of Chicago, and colleagues assessed the pharmacokinetics of an etonogestrel in 13 obese African-American women (body mass index of 30 kg/m² or greater) and four normal-weight white women (body mass index of less than 25 kg/m²). After insertion, plasma etonogestrel levels were measured every 50 hours, though 300 hours, then at three months and six months.

The researchers found that etonogestrel levels were consistently lower in the and 31 to 63 percent lower than the normal-weight women, though the differences did not reach statistical significance. Peak plasma levels were achieved at 150 hours post insertion. There were no serious adverse events and obese women rated the implant as highly acceptable.

"Obese women have lower plasma etonogestrel concentration than normal-weight women in the first six months after ," Mornar and colleagues write. "These findings should not be interpreted as decreased contraceptive effectiveness without additional considerations."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Breast cancer more aggressive among obese women

Mar 14, 2008

Women with breast cancer have more aggressive disease and lower survival rates if they are overweight or obese, according to findings published in the March 15 issue of Clinical Cancer Research, a journal of the American Associ ...

Recommended for you

Cesarean section rates in Portugal decline by 10 percent

Mar 02, 2015

A new study reports a significant decline in the rate of cesarean section (C-section) births in Portugal. Findings published in Acta Obstetricia et Gynecologica Scandinavica, a journal of the Nordic Federation of Societies of Obs ...

Bariatric surgery affects risk of pregnancy complications

Feb 25, 2015

Bariatric surgery has both a positive and negative influence on the risk of complications during subsequent pregnancy and delivery, concludes a new study from Karolinska Institutet in Sweden. The results, which are published ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.