Experimental combo treatment worsens type 1 diabetes

August 24, 2012
Experimental combo treatment worsens type 1 diabetes
A treatment regimen that is effective in preventing diabetes in a mouse model of the disease leads to worsening disease in patients with type 1 diabetes, according to a study published online June 20 in Diabetes.

(HealthDay)—A treatment regimen that is effective in preventing diabetes in a mouse model of the disease leads to worsening disease in patients with type 1 diabetes, according to a study published online June 20 in Diabetes.

Following up on previous results in a mouse model of autoimmune diabetes showing that treatment with and interleukin-2 (IL-2) prevented the disease, S. Alice Long, Ph.D., from the Benaroya Research Institute in Seattle, and colleagues performed a phase I trial of oral rapamycin (daily for three months) and subcutaneous IL-2 (three times per week for one month) in nine patients with type 1 diabetes.

The researchers observed a transient worsening of diabetes (based on metabolic and clinical data) and β-cell function (based on C-peptide levels) in all subjects. There was a transient increase in the levels of regulatory T cells, but also an increase in and eosinophils. The frequencies of effector T-cell subsets were not affected.

"Thus, rapamycin/IL-2 therapy boosted , but also promoted a proinflammatory environment that may have resulted in transient β-cell dysfunction," Long and colleagues conclude. "Such results highlight the difficulties in translating therapies to the clinic and emphasize the importance of broadly interrogating the immune system to evaluate the effects of therapy."

Glucometers and test strips were donated by LifeScan. One author disclosed financial interests in Novartis.

Explore further: Oxygen treatment beneficial in diabetes-prone mice

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Oxygen treatment beneficial in diabetes-prone mice

May 8, 2012

(HealthDay) -- Hyperbaric oxygen treatment of a preclinical diabetes mouse model reduces the incidence of diabetes and preserves insulin-producing β-cells, according to a study published online May 7 in Diabetes.

Turmeric component reduces type 2 diabetes incidence

July 12, 2012

(HealthDay) -- A component of turmeric -- curcumin -- reduces the incidence of type 2 diabetes and improves β-cell function in adults with prediabetes, according to a study published online July 6 in Diabetes Care.

Recommended for you

Do germs cause type 1 diabetes?

May 16, 2016

Germs could play a role in the development of type 1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, new research suggests.

Melatonin signaling is a risk factor for type 2 diabetes

May 12, 2016

A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person, suggests a study published May 12, 2016 in Cell Metabolism. Up to 30 percent of the population may be predisposed ...

New gene for familial high cholesterol

May 12, 2016

New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Familial hypercholesterolemia is the most common genetic disorder leading to premature ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.