Study pinpoints genes involved in diet-mediated life-extension
Researchers at the University of Liverpool have developed a new method to identify genes involved in diet-mediated life-extension which allowed them to find three novel genes that extend lifespan in yeast.
The researchers in Liverpool, in collaboration with researchers at the University of Arkansas, studied dietary restriction, which consists of limiting certain factors in diet (like calories) without malnutrition and has been shown to increase lifespan from yeast to monkeys. Many genes had been associated with dietary restriction before, and the researchers developed a method to study how the genes interact with each other as part of networks to decipher the mechanisms involved and find possible missing links. This allowed them to identify new genes that mediate life-extension in response to dietary restriction. Three of such genes they then showed to extend lifespan in yeast via dietary restriction-related mechanisms.
Some of the new genes identified may have similar functions in humans and could be potential targets for anti-ageing interventions. Dr Joao Pedro de Magalhaes, who led the study, explains: "Some targets for retarding ageing in humans being clinically tested were initially discovered in yeast, so we definitely want to continue this work with a view of ultimately tackling the human ageing process and developing treatments for age-related diseases. Besides, our method can be used to predict genes involved in life-extension mediated by dietary restriction in mammals and even in humans. We just tested our predictions in yeast because it was quicker and cheaper, but we are now looking to obtain funding to pursue this line of research in more complex models. I am definitely optimistic that it is possible to develop an anti-ageing pill."
The work is published in August in PLoS Genetics.
More information: doi:10.1371/journal.pgen.1002834
Journal reference: PLoS Genetics
Provided by University of Liverpool
- Cutting calories might help you live longer, but not without increased physical activity Jul 03, 2012 | not rated yet | 0
- Study identifies genes that protect against aging Apr 20, 2009 | not rated yet | 0
- Key protein may explain the anti-aging and anti-cancer benefits of dietary restriction May 22, 2009 | not rated yet | 0
- Is the 'longevity gene' nearing the end of its life? Sep 21, 2011 | not rated yet | 0
- 'Anti-Atkins' low protein diet extends lifespan in flies Oct 01, 2009 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Researchers from Queen Mary, University of London have led the largest sequencing study of human disease to date, investigating the genetic basis of six autoimmune diseases.
Genetics 22 hours ago | 4.5 / 5 (4) | 0 |
University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral ...
Genetics May 20, 2013 | 5 / 5 (1) | 0 |
Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock.
Genetics May 16, 2013 | 3 / 5 (1) | 1 |
Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of ...
Genetics May 16, 2013 | 5 / 5 (1) | 3 |
Ethicists provide framework supporting new recommendations on reporting incidental findings in gene sequencing
In a paper published in Science Express, a group of experts led by bioethicists in the Center for Medical Ethics and Health Policy at Baylor College of Medicine provide a framework for the new American College of Medical Geneti ...
Genetics May 16, 2013 | not rated yet | 0
A known difficulty in fighting influenza (flu) is the ability of the flu viruses to mutate and thus evade various medications that were previously found to be effective. Researchers at the Hebrew University of Jerusalem have ...
1 minute ago | not rated yet | 0 |
22 May 2013, Paris, France: The Lotus Valve, a second-generation transcatheter aortic valve implantation (TAVI) device, was successfully implanted in all of the first 60 patients in results from REPRISE II reported at EuroPCR ...
3 minutes ago | not rated yet | 0
A potentially ground-breaking human drug trial is currently underway, which aims to discover whether blood pressure medication can slow or halt the progression of Alzheimer's Disease (AD). This is the latest ...
11 minutes ago | not rated yet | 0
Scientists at Newcastle University have shed new light on how the brain tunes in to relevant information.
1 hour ago | 5 / 5 (1) | 0 |
Professor Michael Jennings, Deputy Director of the Institute for Glycomics at Griffith University, was part of an international team that discovered the previously unknown pathway of how the bacterium colonizes people.
1 hour ago | 5 / 5 (1) | 0 |
(Medical Xpress)—Research by U of T Mississauga psychology professor Glenn Schellenberg reveals that two key personality traits – openness-to-experience and conscientiousness—predict better than IQ ...
1 hour ago | not rated yet | 0 |