Study examines risk of heart attack associated with various psoriasis treatments

Use of tumor necrosis factor (TNF) inhibitors for treatment of psoriasis is associated with a significantly reduced risk for heart attack (myocardial infarction) compared to other forms of treatment, according to a report published Online First by Archives of Dermatology.

"The effect of systemic treatment for psoriasis on cardiovascular disease has been largely unexplored," the authors write as background information in the study. "The primary objective of this study was to assess whether patients with psoriasis treated with TNF inhibitors have a decreased risk of MI [] compared with those not treated with TNF inhibitors (i.e., those who received oral agents/phototherapy or )."

Jashin J. Wu, M.D., of the Kaiser Permanente Los Angeles Medical Center, and colleagues, conducted a retrospective study that included patients with at least three ICD-9-CM codes for psoriasis or psoriatic arthritis, without antecedent MI, between January 2004 and November 2010.

Of the 8,845 patients included in the study, 5,075 (57.4 percent) were not treated with any systemic therapy or phototherapy (topical treatment group), 1,673 (18.9 percent) received a TNF inhibitor for at least two consecutive months (TNF treatment group) and 2,097 (23.7 percent) were treated with oral systemic agents or phototherapy (oral/phototherapy treatment group).

After adjusting for other MI risk factors, patients in TNF inhibitor treatment group and the oral/phototherapy treatment group had a significantly lower risk of MI (50 percent and 46 percent, respectively) compared with patients in the topical treatment group. Differences in risk between the TNF inhibitor group and oral/phototherapy group did not reach statistical significance.

"Future prospective studies are needed and warranted to determine whether the use of TNF inhibitors may reduce the risk of major adverse cardiovascular events in patients with systemic ," the authors conclude.

More information: Arch Dermatol. Published online August 20, 2012. doi:10.1001/archdermatol.2012.2502

Related Stories

Study compares effectiveness of psoriasis treatments

Apr 20, 2012

(HealthDay) -- The effectiveness of therapies for psoriasis is variable, and may be lower in real-world settings than in trial settings, according to a study published in the April issue of the Archives of ...

Recommended for you

UN says Syria vaccine deaths was an NGO 'mistake'

5 hours ago

The recent deaths of Syrian children after receiving measles vaccinations was the result of a "mistake" by a non-governmental partner who mixed in a muscle relaxant meant for anesthesia, a spokesman for the U.N. secretary-general ...

First US child dies from enterovirus D68

5 hours ago

A child in the northeastern US state of Rhode Island has become the first to die from an ongoing outbreak of a respiratory virus, enterovirus D68, health officials said Wednesday.

US Ebola patient had contact with kids: governor

5 hours ago

A man who was diagnosed with Ebola in virus in Texas came in contact with young children, and experts are monitoring them for any signs of disease, governor Rick Perry said Wednesday.

UN worker dies of suspected Ebola in Liberia

6 hours ago

The United Nations mission in Liberia announced on Wednesday the first suspected victim among its employees of the deadly Ebola epidemic ravaging the impoverished west African nation.

User comments