Lung cancer risk unaffected by metformin use in diabetes

(HealthDay)—Patients with type 2 diabetes who take metformin do not have a reduced risk of lung cancer, in contrast to previous observational studies, according to a study published online Aug. 24 in Diabetes Care.

To determine whether metformin use in is associated with the incidence of lung cancer, Brielan B. Smiechowski, from the Jewish General Hospital in Montreal, and colleagues analyzed data from 115,923 patients with type 2 diabetes newly treated with oral hypoglycemic agents.

The researchers found that 1,061 patients were diagnosed with lung cancer during follow-up. Based on matching each lung cancer case with up to 10 matched control subjects, metformin had no effect on the lung cancer rate (rate ratio, 0.94). Smoking status had no effect. No dose-response was noted based on number of prescriptions received, cumulative duration of use, and cumulative dose.

"Metformin use is not associated with a decreased risk of lung cancer in patients with type 2 diabetes," Smiechowski and colleagues conclude. "The decreased risk reported in other is likely due to bias from methodological shortcomings."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Metformin may prevent lung cancer in smokers

Apr 19, 2010

Metformin, a mainstay of treatment for patients with type 2 diabetes, may soon play a role in lung cancer prevention if early laboratory research presented here at the AACR 101st Annual Meeting 2010 is confirmed in clinical ...

Diabetes linked to lung cancer in postmenopausal women

May 30, 2012

(HealthDay) -- Postmenopausal women with diabetes are at a significantly higher risk of developing lung cancer, particularly if they require insulin therapy, according to research published online May 22 in ...

Metformin appeared to slow prostate cancer growth

Apr 01, 2012

The use of metformin in men with prostate cancer before prostatectomy helped to reduce certain metabolic parameters and slow the growth rate of the cancer, according to the results of a phase II study.

Recommended for you

Screening for diabetes at dental visits using oral blood

Feb 26, 2015

It is estimated that 8.1 million of the 29.1 million Americans living with diabetes are undiagnosed and many who have diabetes have poor glycemic control. Given that each year many Americans visit a dental provider but not ...

CBT, sertraline insufficient in diabetes and depression

Feb 26, 2015

(HealthDay)—For patients with diabetes and depression, improvements in depression are seen with cognitive behavioral therapy (CBT) or sertraline, with a significant advantage for sertraline, but glycemic ...

Early signs in young children predict type 1 diabetes

Feb 26, 2015

New research shows that it is possible to predict the development of type 1 diabetes. By measuring the presence of autoantibodies in the blood, it is possible to detect whether the immune system has begun to break down the ...

Daily menu plan reduces blood sugar significantly

Feb 25, 2015

A large group of people with diabetes who followed a menu plan created by University of Alberta nutrition researchers for just three months significantly reduced their blood sugar levels.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.