Mathematical modelling to tackle metabolic diseases
Predictive mathematical models of signalling pathways are powerful biological tools that could be used for drug development. Using a similar approach, European scientists developed a computational model for answering research questions regarding the AMP-activated protein kinase pathway.
AMP-activated protein kinase has a master regulatory role in monitoring the cellular energy status. The signalling pathway involving AMP-activated protein kinase controls energy production and consumption, thereby affecting most intracellular biological processes.
The EU 'Systems biology of the AMP-activated protein kinase pathway' (Ampkin) project was designed to contribute to our understanding of how the AMP-activated protein kinase pathways operate. More specifically, project scientists planned to generate predictive kinetic mathematical descriptions of pathway activation/deactivation in order to identify potential drug targets to treat human metabolic diseases.
Using existing data of protein, mRNA expression and metabolite levels enabled scientists to capture the pathway's dynamics and design kinetics models. Comparison of the yeast and mammalian pathways indicated that AMP-activated protein kinase has similar targets and physiological roles in both systems.
Additionally, assay tools were generated for the majority of the steps of the AMP cascade, thereby maximising the use of real data in the mathematical model. Combined with quantitative dynamic datasets generated following activation and deactivation of the AMP-activated protein kinase pathway, it was possible to build mathematical models for the yeast homologue, Snf1.
Importantly, the Ampkin model was designed to assess system perturbations and potentially be used for drug screening. By integrating modelling with experimentation, project partners managed to continuously improve the AMP-activated protein kinase model. This allowed them to address research-related questions and hopefully provide answers for metabolic diseases such as obesity and type II diabetes.
Provided by CORDIS
- AMPK amplifies Huntington's disease Jul 18, 2011 | not rated yet | 0
- Real-time monitoring of cellular signalling events May 02, 2012 | not rated yet | 0
- Hormone in fruit flies sheds light on diabetes cure, weight-loss drug for humans Aug 09, 2012 | not rated yet | 0
- Protein found that slows hepatitis C growth in liver cells Apr 27, 2007 | not rated yet | 0
- Exploring the relation between stem cells and tumor growth Jul 16, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How can there be villous adenoma in colon, if there are no villi there
9 hours ago As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
- More from Physics Forums - Medical Sciences
More news stories
The human gut is loaded with commensal bacteria – "good" microbes that, among other functions, help the body digest food. The gastrointestinal tract contains literally trillions of such cells, and yet the ...
Medical research 3 hours ago | 5 / 5 (1) | 0 |
Swiss scientists reveal the mechanism responsible for aging hidden deep within mitochondria—and dramatically slow it down in worms by administering antibiotics to the young.
Medical research 3 hours ago | 4.5 / 5 (2) | 0 |
On May 22, JoVE will publish details of a technique to measure the health of human genetic material in relation to a patient's age. The method is demonstrated by the laboratory of Dr. Gil Atzmon at New York's Albert Einste ...
Medical research 6 hours ago | not rated yet | 0
(Medical Xpress)—Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow ...
Medical research 8 hours ago | not rated yet | 0 |
Medical researchers discover new ways to target, develop and design drugs to prevent and treat viral infection
Researchers at the University of Alberta have discovered a new drug target, developed a new drug and identified a new way to design drugs—all of which could be a winning combination in the battle against viruses.
Medical research 8 hours ago | 4 / 5 (1) | 0 |
(HealthDay)—Migraines and depression can each cause a great deal of suffering, but new research indicates the combination of the two may be linked to something else entirely—a smaller brain.
15 minutes ago | not rated yet | 0 |
A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine ...
1 hour ago | not rated yet | 0 |
Until now, little was scientifically known about the human potential to cultivate compassion—the emotional state of caring for people who are suffering in a way that motivates altruistic behavior.
39 minutes ago | not rated yet | 0 |
A man who had contracted the coronavirus has died in Saudi Arabia, raising the death toll in the kingdom from the SARS-like virus to 17, the health ministry announced on its website on Wednesday.
33 minutes ago | not rated yet | 0
GlaxoSmithKline PLC says it's starting an unusual collaboration with the U.S. government to develop several antibiotics for both bioterrorism threats and bacterial infections resistant to current medicines.
32 minutes ago | not rated yet | 0
What effect does a father's depression have on his young son or daughter? When fathers report a high level of emotional intimacy in their marriage, their children benefit, said a University of Illinois study.
1 hour ago | not rated yet | 0