Even minor physical activity may benefit bone health in premenopausal women
A study to be published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM) suggests that physical activity for premenopausal women is very effective in reducing sclerostina known inhibitor of bone formation. In addition, physical training enhances IGF-1levels, which have a very positive effect on bone formation.
Bone is a tissue that is always changing due to hormonal changes and physical activity, or lack thereof. Sclerostin is a glycoprotein produced almost exclusively by osteocytes, the most abundant cells found in human bone. Upon release, sclerostin travels to the surface of the bone where it inhibits the creation of cells that help bones develop.
"Physical activity is good for bone health and results in lowering sclerostin, a known inhibitor of bone formation and enhancing IGF-1 levels, a positive effector on bone health" said Mohammed-Salleh M. Ardawi, PhD, FRCPath, professor at the Center of Excellence for Osteoporosis Research and Faculty of Medicine at King Abdulaziz University in Saudi Arabia and lead researcher for this study. "We also found physical activity training that enhances mechanical loading in combination with anabolic therapeutic agents will have added positive effect on bone health, particularly bone formation."
A total of 1,235 randomly selected premenopausal women were involved in this cross-sectional study. Researchers followed up 58 of these women during an eight-week course of physical activity training and compared them with 62 controls. All women were medically examined and measurements were taken for bone mineral density, bone turnover markers and serum sclerostin and IGF-1.
At the conclusion of the study, it was discovered that those women who had more than two hours of physical activity per week had significantly lower levels of serum sclerostin, but had higher IGF-1 levels than those women who had less than two hours of physical activity per week.
"Physical activity training is conceptually simple, inexpensive, and can serve practical purposes including reducing the risk of low bone mass, osteoporosis, and consequently fractures," said Ardawi. "Our study found that even minor changes in physical activity were associated with clear effects on serum levels of sclerostin, IGF-1 and bone turnover markers."
More information: The article "Physical Activity in Relation to Serum Sclerostin, Insulin-like Growth Factor-1 (IGF-1), and Bone Turnover Markers in Healthy Premenopausal Women: A Cross-sectional and Longitudinal Study" will appear in the October 2012 issue of JCEM.
Journal reference: Journal of Clinical Endocrinology and Metabolism
Provided by The Endocrine Society
- Bone loss prevention experiment on the last space shuttle flight Jul 05, 2011 | not rated yet | 0
- Exercise in early 20s may lower risk of osteoporosis Feb 13, 2012 | not rated yet | 0
- Increase in physical activity in men optimizes peak bone mass May 21, 2012 | not rated yet | 0
- Dairy foods may improve bone health during diet and exercise in overweight premenopausal women Nov 09, 2011 | not rated yet | 0
- Mechanisms for a beneficial effect of moderate alcohol consumption on osteoporosis in women Aug 02, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Classical and Quantum Mechanics via Lie algebras
Apr 15, 2011 I'd like to open a discussion thread for version 2 of the draft of my book ''Classical and Quantum Mechanics via Lie algebras'', available online at http://lanl.arxiv.org/abs/0810.1019 , and for the...
- More from Physics Forums - Independent Research
More news stories
Family caregivers of older adults with dementia are less stressed and their moods are improved on days when dementia patients receive adult day services (ADS), according to Penn State researchers.
Health 1 hour ago | not rated yet | 0
Given the implications for the overall health, development, and academic success of children, schools should play a primary role in ensuring that all students have opportunities to engage in at least 60 minutes per day of ...
Health 1 hour ago | not rated yet | 0
Over 70 per cent of people who hold a personal budget for social care said it led to greater independence and support according to the latest survey.
Health 4 hours ago | not rated yet | 0
A new smartphone application, developed by scientists at the University of Ulster, which could help older people engage fully in an increasingly self-serve society, may be ready for use by the end of the ...
Health 5 hours ago | not rated yet | 0
Little is known about why asthma develops, how it constricts the airway or why response to treatments varies between patients. Now, a team of researchers at Weill Cornell Medical College, Columbia University Medical Center ...
10 minutes ago | not rated yet | 0 |
(Medical Xpress)—The human brain is able to identify individuals' voices by comparing them against an internal 'average voice' prototype, according to neuroscientists.
1 minute ago | not rated yet | 0 |
A new study determined that children and adolescents with seizures involving the temporal lobe are likely to have clinically significant behavioral problems and psychiatric illness, especially depression. Findings published ...
12 minutes ago | not rated yet | 0
A brief visual task can predict IQ, according to a new study. This surprisingly simple exercise measures the brain's unconscious ability to filter out visual movement. The study shows that individuals whose ...
1 hour ago | 4.7 / 5 (3) | 0 |
Gaucher disease causes debilitating and sometimes fatal neurodegeneration in early childhood. Recent studies have uncovered a link between the mutations responsible for Gaucher disease and an increased risk ...
1 hour ago | not rated yet | 0 |