Skin intrinsic fluorescence tied to coronary artery disease

Skin intrinsic fluorescence tied to coronary artery disease
Skin intrinsic fluorescence is significantly associated with coronary artery disease in middle-aged adults with a long duration of type 1 diabetes, according to a study published online July 30 in Diabetes Care.

(HealthDay) -- Skin intrinsic fluorescence (SIF) is significantly associated with coronary artery disease (CAD) in middle-aged adults with a long duration of type 1 diabetes, according to a study published online July 30 in Diabetes Care.

Baqiyyah N. Conway, Ph.D., of Vanderbilt University in Nashville, Tenn., and colleagues conducted a study involving a total of 172 middle-aged adults with type 1 diabetes (mean disease duration, 36 years) to evaluate the relationship between SIF and CAD and whether this relationship was independent of renal disease.

The researchers found that 30 of the participants had CAD, and that SIF levels were significantly higher in those participants with CAD. SIF correlated strongly with CAD (odds ratio [OR], 3.5). The correlation persisted, after adjustment for age, diabetes duration, and cumulative glycemic exposure (OR, 2.4), and was stronger for men (OR, 5.6) than for women (OR, 1.4; 95 percent confidence interval [CI], 0.61 to 3.3). With inclusion of nephropathy in the model, the OR for SIF declined to 1.7 (95 percent CI, 0.89 to 3.4).

"In conclusion, we have demonstrated a strong association between SIF and CAD in middle-aged individuals with ," the authors write. "SIF partially reflects the influence of skin advanced glycation end products, skin markers of oxidative stress and , subject age, diabetes duration, long-term glycemic control, and renal disease, which are associated with increased CAD risk."

Several authors are employees of or disclosed to Vera Light Inc., which funded the study and manufactures the SCOUT DS used to determine SIF.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

BPA exposure possibly linked to future heart disease

date Feb 29, 2012

(HealthDay) -- Healthy people exposed to higher levels of the controversial chemical bisphenol A (BPA), found in plastics, may be more likely to develop heart disease, according to a study published online ...

Nonsupportive family members sabotage diabetes self-Care

date May 02, 2012

(HealthDay) -- Diabetes patients with nonsupportive family members are less adherent to their diabetes medication regimen and have worse glycemic control, according to a study published online April 26 in ...

Recommended for you

Faster heart rate linked to diabetes risk

date May 22, 2015

An association between resting heart rate and diabetes suggests that heart rate measures could identify individuals with a higher future risk of diabetes, according to an international team of researchers.

EBV co-infection may boost malaria mortality in childhood

date May 21, 2015

Many people who live in sub-Saharan Africa develop a natural immunity to malaria, through repeated exposure to Plasmodium parasites. Even so, the disease kills close to half a million children per year, according ...

Three important things you didn't know about diabetes

date May 21, 2015

When we think of diabetes, we tend to think of rich people with poor lifestyles. A chronic disease linked with obesity, heart disease and worse outcomes for some infectious diseases, diabetes tends to be ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.