Tissue platinum concentrations linked to response in NSCLC

Tissue platinum concentrations linked to response in NSCLC
For patients with non-small-cell lung cancer who undergo neoadjuvant platinum-based chemotherapy, tissue platinum concentrations correlate positively with improved outcome, according to a study published online Aug. 13 in the Journal of Clinical Oncology.

(HealthDay) -- For patients with non-small-cell lung cancer (NSCLC) who undergo neoadjuvant platinum-based chemotherapy, tissue platinum concentrations correlate positively with improved outcome, according to a study published online Aug. 13 in the Journal of Clinical Oncology.

Eric S. Kim, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues used flameless atomic absorption spectrophotometry to measure total platinum concentrations in 44 archived fresh-frozen specimens from patients who underwent surgical resection after neoadjuvant platinum-based chemotherapy. The effect of tissue platinum concentration on response and survival was examined.

The researchers observed a significant association between tissue platinum concentration and percent reduction in . This association was also seen with cisplatin, carboplatin, and all histology subgroups. Variables such as the number of cycles and time lapse from last chemotherapy had no significant impact on platinum concentration. Time to recurrence, progression-free survival, and overall survival were significantly longer in patients with higher platinum concentration, after adjustment for the number of cycles.

"Our data strongly support reduced drug accumulation as a significant mechanism of platinum resistance," the authors write. "Enhanced understanding of the molecular mechanism of platinum accumulation by will be necessary to identify surrogate biomarkers for platinum accumulation that could be developed prospectively for individualizing therapy."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Drug cocktail boosts ovarian cancer survival time

Jun 02, 2012

A drug cocktail that combines chemotherapy with Avastin was shown to double the amount of time patients lived without progression of ovarian cancer, according to research released Saturday.

Platinum and light together fight cancer

Sep 14, 2010

(PhysOrg.com) -- Researchers continue to search for cancer treatments that effectively destroy tumor cells while protecting surrounding healthy tissue and the body. One intriguing approach involves photoactivated ...

Recommended for you

Exercising restraint to stall tumor growth

6 hours ago

Many proteins undergo an assembly line-style process of glycosylation as they travel from a cellular structure called the endoplasmic reticulum (ER) to the Golgi apparatus and on through its various compartments, ...

User comments