Tissue platinum concentrations linked to response in NSCLC

August 14, 2012
Tissue platinum concentrations linked to response in NSCLC
For patients with non-small-cell lung cancer who undergo neoadjuvant platinum-based chemotherapy, tissue platinum concentrations correlate positively with improved outcome, according to a study published online Aug. 13 in the Journal of Clinical Oncology.

(HealthDay) -- For patients with non-small-cell lung cancer (NSCLC) who undergo neoadjuvant platinum-based chemotherapy, tissue platinum concentrations correlate positively with improved outcome, according to a study published online Aug. 13 in the Journal of Clinical Oncology.

Eric S. Kim, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues used flameless atomic absorption spectrophotometry to measure total platinum concentrations in 44 archived fresh-frozen specimens from patients who underwent surgical resection after neoadjuvant platinum-based chemotherapy. The effect of tissue platinum concentration on response and survival was examined.

The researchers observed a significant association between tissue platinum concentration and percent reduction in . This association was also seen with cisplatin, carboplatin, and all histology subgroups. Variables such as the number of cycles and time lapse from last chemotherapy had no significant impact on platinum concentration. Time to recurrence, progression-free survival, and overall survival were significantly longer in patients with higher platinum concentration, after adjustment for the number of cycles.

"Our data strongly support reduced drug accumulation as a significant mechanism of platinum resistance," the authors write. "Enhanced understanding of the molecular mechanism of platinum accumulation by will be necessary to identify surrogate biomarkers for platinum accumulation that could be developed prospectively for individualizing therapy."

Explore further: Platinum and light together fight cancer

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Platinum and light together fight cancer

September 14, 2010

(PhysOrg.com) -- Researchers continue to search for cancer treatments that effectively destroy tumor cells while protecting surrounding healthy tissue and the body. One intriguing approach involves photoactivated drugs: an ...

Large or small, platinum clusters provide new insights

April 28, 2011

Using Environmental Molecular Sciences Laboratory's high-performance supercomputing capabilities, scientists helped resolve longstanding controversies about the effect of platinum cluster size on some emissions-reducing reactions ...

Drug cocktail boosts ovarian cancer survival time

June 2, 2012

A drug cocktail that combines chemotherapy with Avastin was shown to double the amount of time patients lived without progression of ovarian cancer, according to research released Saturday.

Recommended for you

Oxygen can impair cancer immunotherapy in mice

August 25, 2016

Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer ...

Stem cell propagation fuels cancer risk in different organs

August 25, 2016

The idea that stem cells - special cells that divide to repair and generate tissues - might be the major determinant of cancer risk has provoked great debate in the scientific community. Some researchers maintain that environmental ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.