Treatment of heart attacks with APOSEC: further mechanism unravelled
The protein concentrate APOSEC, obtained from white blood cells, when given intravenously 40 minutes after an acute myocardial infarction, largely prevents scarring of the cardiac muscle. These were the findings of Hendrik Jan Ankersmit, Head of the Christian Doppler Laboratory for Diagnosis and Regeneration in Cardiac and Thoracic Diseases at the MedUni Vienna, which were unveiled back in the autumn of 2011. A study by a team of researchers led by Ankersmit has now unravelled further mechanisms responsible for how APOSEC works.
A lack of oxygen, due to inflammation and "sticking" of the incoming blood supply caused by platelets in the blood can lead to microvascular obstruction (MVO) in the tissue of the affected organ. In ischaemic conditions (such as myocardial infarctions, strokes, etc.), an additional drug treatment that combines the effects of vasodilation, platelet aggregation inhibition and immunomodulation would be ideal.
"Through fundamental research, we have demonstrated that APOSEC triggers several of these protective mechanisms at once. APOSEC contains, among others, nitrogen monoxide (NO), which is responsible for the vasodilating and platelet aggregation inhibiting effect after an acute myocardial infarction. In collaboration with the working groups led by Prof. Mariann Gyöngyösi (Cardiology, MedUni Vienna) and Prof. Ivo Volf (Medical Physiology, MedUni Vienna), we have been able to demonstrate in large animal experiments that ECG changes in animals treated with APOSEC resolved and the signs of MVO were prevented."
APOSEC is a product containing soluble proteins that are excreted by white blood cells after they are irradiated. The recovery of white blood cells as 'bio-reactors' is simple and can be compared in terms of effort to a regular blood donation. The product can be produced in advance and is easily available if the worst happens. A GMP facility is currently being set up in collaboration with the Red Cross's Blood Donation Centre in Linz (Dr. Christian Gabriel) to manufacture this "biological" under good manufacturing practice (GMP) conditions.
As part of his PhD thesis, Dr. Konrad Hoetzenecker from the Department of Thoracic Surgery was also able to demonstrate that APOSEC has an immunosuppressive effect in an experimental cardiac muscle inflammation model. Working with Prof. Urs Eriksson from the University of Zürich, it was possible to demonstrate that CD4-positive T cells are forced under the influence of Caspase-8 to undergo programmed cell death (apoptosis). This explains a further fundamental scientific aspect of the effect of APOSEC.
More information: "Secretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascluar obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation." K. Hoetzenecker, et al. Basic Res Cardiol (2012) 107:292; Article DOI: 10.1007/s00395-012-0292-2
Provided by Medical University of Vienna
- Specific blood-derived cells promote survival in heart attack model Jun 16, 2010 | not rated yet | 0
- Promising and perilous? The ambivalent role of the CXCL12/ CXCR4 axis in heart repair Nov 30, 2011 | not rated yet | 0
- Can stem cells heal damaged hearts? No easy answers, but some signs of hope Oct 08, 2008 | not rated yet | 0
- Diseased hearts to heal themselves in future Nov 11, 2011 | not rated yet | 0
- Hormone reduces risk of heart failure from chemotherapy Aug 04, 2011 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Faraday's law on circular wire
21 minutes ago In my examples on Faraday's law in my book, they use a drawing of a magnet approaching a circular wire. The changing magnetic flux then induces an...
Specific Exergy vs Specific Flow Exergy
1 hour ago I'm having some difficulty understanding exactly what the difference between the definitions of these values are. As I understand it, in terms of...
The Durability of Bone: Long Falls
10 hours ago I am doing a paper on the physics in Valve's Portal and got interested in the "Long Fall Boots" that prevent any damage no matter how far you fall. I...
Is energy convertible to matter?
11 hours ago Can we convert energy to matter?
Rotating electron as a dipole is this right?
14 hours ago An electron as shown by the Stern Gerlach experiment behaves like a dipole (albeit only in one of two states). I have been trying to figure out how...
Dipole term in multipole expansion
18 hours ago Hi. I'm having some difficult in understanding something about the dipole term in a multipole expansion. Griffiths writes the expansion as a sum of...
- More from Physics Forums - Classical Physics
More news stories
The Orsiro stent, which is a novel stent platform eluting sirolimus from a biodegradable polymer, demonstrated non-inferiority to the Xience Prime everolimus-eluting stent for the primary angiographic endpoint of in-stent ...
Cardiology 15 hours ago | 5 / 5 (1) | 0
One-year results from SOURCE XT – one of the largest, post-approval transcatheter aortic valve implantation (TAVI) registries to-date – reported today at EuroPCR 2013 show good clinical outcomes in routine clinical practice, ...
Cardiology 15 hours ago | not rated yet | 0
A drug commonly used to treat depression and anxiety may improve a stress-related heart condition in people with stable coronary heart disease, according to researchers at Duke Medicine.
Cardiology 16 hours ago | 5 / 5 (1) | 0 |
(Medical Xpress)—In a recent subgroup analysis of the largest blood pressure treatment trial in history, University of Alabama at Birmingham (UAB) researchers found that women and men react the same to ...
Cardiology May 21, 2013 | 5 / 5 (1) | 0
(Medical Xpress)—Scientists supported by the National Institutes of Health have a new theory as to why a woman's fertility declines after her mid-30s. They also suggest an approach that might help slow ...
19 minutes ago | not rated yet | 0 |
Medical researchers discover new ways to target, develop and design drugs to prevent and treat viral infection
Researchers at the University of Alberta have discovered a new drug target, developed a new drug and identified a new way to design drugs—all of which could be a winning combination in the battle against viruses.
39 minutes ago | not rated yet | 0 |
Beta-blockers, normally used for high blood pressure, could enhance the effectiveness of chemotherapies in treating neuroblastoma, a type of children's cancer, according to a new study published in the British Jo ...
49 minutes ago | not rated yet | 0
Cancer survivors are no more likely to stop smoking, cut down on alcohol, or exercise more often than the general population, according to new research published in the British Journal of Cancer today (Wednesday)
39 minutes ago | not rated yet | 0
(Medical Xpress)—Do ethicists engage in better moral behavior than other professors? The answer is no. Nor are they more likely than nonethicists to act according to values they espouse, according to researchers from the ...
39 minutes ago | not rated yet | 0
The University of Gothenburg Vaccine Research Institute (GUVAX) announces successful results in a placebo controlled phase I study of an oral, inactivated Escherichia coli diarrhea vaccine.
9 minutes ago | not rated yet | 0