Children exposed to two phthalates have elevated risk of asthma-related airway inflammation

September 5, 2012

Children exposed to diethyl phthalate (DEP) and butylbenzyl phthalate (BBzP)—phthalate chemicals commonly found in personal care and plastic products—have elevated risk of asthma-related airway inflammation, according to researchers at Columbia Center for Children's Environmental Health (CCCEH) at the Mailman School of Public Health.

Of the 244 children aged 5 to 9 in the study, all had detectable levels of phthalates in their urine although these varied over a wide range. Higher levels of both phthalates were associated with higher levels of nitric oxide in exhaled breath, a of . The association between BBzP exposure and airway inflammation was especially strong among children who had recently reported wheeze, a common symptom of asthma. Results were recently published online in the American Journal of Respiratory and .

"While many factors contribute to childhood asthma, our study shows that exposure to phthalates may play a significant role," says Allan Just, PhD, first author on the new CCCEH study and current postdoctoral researcher at the Harvard School of Public Health.

Dr. Just and co-investigators looked at children enrolled in the CCCEH Mothers and Newborns study. All live in Northern Manhattan and the South Bronx where is high. Exposure to phthalates was measured through a urine test, and the level of nitric oxide in the child's exhaled breath was quantified as a marker of airway inflammation.

The study is the first to use exhaled nitric oxide in a study of in children. By using the biomarker in exhaled breath, the researchers overcame a significant hurdle. "Many asthma patients only have a few times a year, making it difficult to discern short-term associations between environmental exposures and the disease," explains Matthew Perzanowski, PhD, senior author and Associate Professor of at the Mailman School. "To solve this problem, we used nitric oxide, which has been shown to be a reliable marker of airway inflammation in response to known asthma triggers like vehicle emissions."

Phthalates are used widely in consumer products, including plastics, vinyl flooring, and personal care products, making exposure ubiquitous in the United States and other developed nations. Phthalates enter the body through ingestion, inhalation, and absorption through the skin. However, past research has suggested inhalation to be a particularly important route of exposure to the two phthalates associated with airway inflammation in this study. Several phthalates are known to disrupt the endocrine system and early-life exposure has been linked not only to asthma but also to adverse neurobehavioral and reproductive effects. A recent study by Dr. Just and other CCCEH investigators found that prenatal exposure to BBzP was linked with increased risk of childhood eczema.

Explore further: Prenatal exposure to phthalates linked to decreased mental and motor development

Related Stories

Phthalates in PVC floors taken up by the body in infants

May 23, 2012

A new study at Karlstad University in Sweden shows that phthalates from PVC flooring materials is taken up by our bodies. Phthalates are substances suspected to cause asthma and allergies, as well as other chronic diseases ...

Recommended for you

Four gut bacteria decrease asthma risk in infants

September 30, 2015

New research by scientists at UBC and BC Children's Hospital finds that infants can be protected from getting asthma if they acquire four types of gut bacteria by three months of age. More than 300 families from across Canada ...

Flu infection reveals many paths to immune response

September 28, 2015

A new study of influenza infection in an animal model broadens understanding of how the immune system responds to flu virus, showing that the process is more dynamic than usually described, engaging a broader array of biological ...

Immune cells may help fight against obesity

September 15, 2015

While a healthy lifestyle and "good genes" are known to help prevent obesity, new research published on September 15 in Immunity indicates that certain aspects of the immune system may also play an important role. In the ...

The Achilles' heel of HIV

September 8, 2015

Researchers at the University of Bonn have discovered how cells in the body can detect the genetic material of so-called retroviruses. The pathogen of the immunodeficiency disease AIDS, the HI-1 virus, also belongs to this ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.