Distinct chromatin patterns linked to heart development

September 17, 2012
Distinct chromatin patterns linked to heart development
Distinct chromatin patterns accompany the development of heart cells from embryonic cells, providing a blueprint that could help identify the causes of congenital heart disease, according to a study published online Sept. 13 in Cell.

(HealthDay)—Distinct chromatin patterns accompany the development of heart cells from embryonic cells, providing a blueprint that could help identify the causes of congenital heart disease, according to a study published online Sept. 13 in Cell.

Joseph A. Wamstad, Ph.D., from the Massachusetts Institute of Technology in Cambridge, and colleagues analyzed the epigenetic changes that occur during the directed differentiation of mouse into cardiomyocytes and used chromatin marks to identify patterns associated with stage-specific development.

The researchers found that distinct chromatin patterns were associated with stage-specific gene expression and could predict sets of functionally related genes, some of which were associated with human disease. In addition, a novel preactivation chromatin pattern was found at the promoters of specific cardiac genes involved in cardiac development and function. They also identified stage-specific distal enhancers that predicted novel transcriptional regulatory networks during differentiation as well as potential new regulators of cardiac development.

"Together, these findings form a basis for understanding developmentally regulated chromatin transitions during lineage commitment and the molecular etiology of ," Wamstad and colleagues conclude.

One author is a scientific founder of iPieirian and is on the scientific advisory boards of iPieirian and RegeneRx Pharmaceuticals.

Explore further: Fibroblasts reprogrammed into functioning heart cells in mice

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

TET proteins drive early neurogenesis

December 7, 2016

The fate of stem cells is determined by series of choices that sequentially narrow their available options until stem cells' offspring have found their station and purpose in the body. Their decisions are guided in part by ...

New, more effective strategy for producing flu vaccines

December 5, 2016

A team of researchers led by Yoshihiro Kawaoka, professor of pathobiological sciences at the University of Wisconsin-Madison School of Veterinary Medicine, has developed technology that could improve the production of vaccines ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.