HbA1c less than 6.5 percent is specific, not sensitive for T1DM

September 2, 2012
HbA1c less than 6.5 percent is specific, not sensitive for T1DM
Using a glycated hemoglobin threshold of ≥6.5 percent is a specific but not sensitive early indicator of type 1 diabetes in high-risk children and young adults, according to a study published in the September issue of Diabetes Care.

(HealthDay)—Using a glycated hemoglobin (HbA1c) threshold of ≥6.5 percent is a specific but not sensitive early indicator of type 1 diabetes (T1D) in high-risk children and young adults, according to a study published in the September issue of Diabetes Care.

Kendra Vehik, Ph.D., of the University of South Florida in Tampa, and colleagues examined the utility of HbA1c as an alternative criterion for impaired glucose tolerance (IGT) or T1D in high-risk individuals younger than 21 years. Participants were recruited from four prospective studies and included 884 participants from TrialNet Natural History; 587 from Diabetes Prevention Trial-Type 1; 420 from Trial to Reduce IDDM in the Genetically at Risk; and 91 from The Environmental Determinants of Diabetes in the Young. All participants had an HbA1c within 90 days of an (OGTT) and a two-hour measure.

The researchers found that using HbA1c of ≥5.7 percent as an indicator of IGT resulted in a very low sensitivity across the studies (8 to 42 percent) and variable specificity (64 to 95 percent). Sensitivity was very low (24 to 34 percent) and specificity high (98 to 99 percent) using HbA1c of ≥6.5 percent as a threshold for T1D. Across the four studies, the of HbA1c varied from 50 to 94 percent.

"HbA1c ≥6.5 percent is a specific but not sensitive early indicator for T1D in high-risk subjects <21 years of age diagnosed by OGTT or asymptomatic hyperglycemia," the authors write. "Redefining the HbA1c threshold is recommended if used as an alternative criterion in diagnosing T1D."

The formulas used in the study were provided free of charge by Mead Johnson Nutrition.

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Elevated glucose associated with undetected heart damage

February 2, 2012

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health suggests that hyperglycemia (high blood sugar) injures the heart, even in patients without a history of heart disease or diabetes. Researchers ...

Study assesses glucose monitoring trends in tweens

April 12, 2012

(HealthDay) -- During the transition to adolescence, children with type 1 diabetes monitor their blood glucose less frequently, resulting in significant increases in HbA1c levels, according to research published online April ...

Sleep apnea severity linked to glycated hemoglobin levels

June 18, 2012

(HealthDay) -- For adults without diabetes, obstructive sleep apnea (OSA) severity is independently associated with impaired glucose metabolism, as measured by glycated hemoglobin (HbA1c) levels, according to a study published ...

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.