Long-term finasteride doesn't impair quality of life

September 13, 2012
Long-term finasteride doesn't impair quality of life
Taking finasteride to prevent prostate cancer does not negatively affect the physical function, mental health, or vitality domains of health-related quality of life, according to a study published online Sept. 12 in the Journal of the National Cancer Institute.

(HealthDay)—Taking finasteride to prevent prostate cancer does not negatively affect the physical function, mental health, or vitality domains of health-related quality of life, according to a study published online Sept. 12 in the Journal of the National Cancer Institute.

Carol M. Moinpour, Ph.D., from the Fred Hutchinson Cancer Research Center in Seattle, and colleagues examined the effect of finasteride on quality of life using data from questionnaires completed by Trial participants, who were randomized to finasteride or placebo for prevention of prostate cancer. Questionnaires were completed at enrollment (three months before randomization), six months after randomization, and annually for seven years. Three health-related quality-of-life domains were measured using the Health Survey Short Form 36: Physical Functioning, Mental Health, and Vitality scales.

The researchers found that finasteride had minor effects on physical function, accounting for less than a one-point difference over time in physical functioning scores. There were significant negative effects on physical function for comorbidities (including , leg pain, and diabetes), current smoking, and time on study. There were no significant effects of finasteride on mental health and vitality at any of the three time points, either in the mixed-effects analyses or in the cross-sectional analysis.

"In conclusion, taking finasteride for seven years did not appear to harm general aspects of health-related quality of life," the authors write.

Merck Inc. provided the drug and placebo used in the study.

Explore further: Generic prostate drug helps find high-risk cancers early

More information: Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Related Stories

Generic prostate drug helps find high-risk cancers early

September 11, 2007

Men now have another good reason to consider taking finasteride, a well-known generic drug that shrinks an enlarged prostate and reduces the risk of getting prostate cancer by 25 percent. A new study from the Southwest Oncology ...

FDA links some prostate drugs to cancer risk

June 9, 2011

(AP) -- The Food and Drug Administration expanded the warning label on a group of prostate drugs Thursday, saying they may increase the risk of a more serious form of prostate cancer.

Hair loss drug shows long-term sexual side effects

July 23, 2012

(HealthDay) -- For men with finasteride-associated side effects, sexual dysfunction may persist for months or years, even after discontinuation of the drug, according to a study published online July 12 in The Journal of ...

Recommended for you

Molecularly shutting down cancer cachexia

August 30, 2016

Healthy fat tissue is essential for extended survival in the event of tumor-induced wasting syndrome (cachexia). In Nature Medicine, researchers at Helmholtz Zentrum München show that selective manipulation of an enzyme ...

Radiologists detect breast cancer in 'blink of an eye'

August 29, 2016

A new study by investigators at Brigham and Women's Hospital in collaboration with researchers at the University of York and Leeds in the UK and MD Andersen Cancer Center in Texas puts to the test anecdotes about experienced ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.