Mild increases in thyroid-stimulating hormone not harmful in the elderly
There is no evidence to link mildly elevated thyroid-stimulating hormone (TSH) levels to an increase in mortality among the elderly, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The findings suggest that reflexively treating mild elevations of TSH in those of advanced age is unnecessary.
TSH is a sensitive, commonly measured test to check thyroid function. TSH levels are inversely related to thyroid hormone levels – thyroid hormone levels below a set-point trigger an increase in TSH. Levels of TSH gradually increase during the aging process, which means that elderly patients are likely to be outside of standard reference ranges and could be labeled with the diagnosis of subclinical hypothyroidism.
"As increasing numbers of people live into their 80s and 90s, it is important to know how to manage their health, including thyroid function," said Anne R. Cappola, MD, ScM of the University of Pennsylvania in Philadelphia, and lead author of the study. "Our study shows that a gradual increase in TSH occurs during healthy aging and that mild increases in TSH are not harmful in the oldest old."
The study began in 1989-1992 and examined 5,888 men and women aged 65 and older. In 2005, 843 surviving participants who had thyroid function testing were examined for changes in physical and cognitive functions. Between 1992 and 2005, participants who were not taking thyroid medication at either visit had a 13 percent increase in TSH. Older participants (mean age 85 years) with increased TSH and subclinical hypothyroidism did not have a higher mortality rate; on the contrary, data suggested that having subclinical hypothyroidism could be protective. In addition, higher levels of thyroid hormone itself were associated with a higher risk of death.
"Our research presents the first data demonstrating longitudinal changes in thyroid function in a cohort of the oldest old," said Cappola. "Our findings suggest that treating mild elevations in TSH in the elderly is unnecessary. Further studies are needed to determine the threshold levels of thyroid function that would benefit from intervention."
More information: The article, "Longitudinal Changes in Thyroid Function in the Oldest Old and Survival: the Cardiovascular Health Study All-Stars Study," appears in the November 2012 issue of JCEM.
Journal reference: Journal of Clinical Endocrinology & Metabolism
Provided by The Endocrine Society
- Elderly may be more likely to die if they have subclinical hyperthyroidism Jun 06, 2011 | not rated yet | 0
- BMC conducts high rates of thyroid testing in pregnant women, study finds Jun 30, 2011 | not rated yet | 0
- Hashimoto's thyroiditis can affect quality of life Feb 25, 2011 | not rated yet | 0
- Pituitary hormone TSH found to directly influence bone growth Sep 13, 2011 | not rated yet | 0
- Low thyroid function common in chronic kidney disease Jun 11, 2008 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.
Medical research May 23, 2013 | 5 / 5 (1) | 0 |
Aortic arch pulse wave velocity, a measure of arterial stiffness, is a strong independent predictor of disease of the vessels that supply blood to the brain, according to a new study published in the June issue the journal ...
Medical research May 23, 2013 | not rated yet | 0
Since the discovery of Prontosil in 1932, sulfonamide antibiotics have been used to combat a wide spectrum of bacterial infections, from acne to chlamydia and pneumonia. However, their side effects can include serious neurological ...
Medical research May 23, 2013 | 3 / 5 (1) | 0 |
Scientists at the National Institutes of Health report they have discovered in mouse studies that a small molecule released in the spinal cord triggers a process that is later experienced in the brain as ...
Medical research May 23, 2013 | 5 / 5 (3) | 0 |
Spanish researchers have discovered that the daily clearance of neutrophils from the body stimulates the release of hematopoietic stem cells from the bone marrow into the bloodstream, according to a report published today ...
Medical research May 23, 2013 | 5 / 5 (2) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
12 hours ago | 5 / 5 (2) | 5
(HealthDay)—Animals make great companions for senior citizens, but elderly people who always drive with a pet in the car are far more likely to crash than those who never drive with a pet, researchers have ...
4 hours ago | not rated yet | 0
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
12 hours ago | not rated yet | 1
Mortality and length of stay are highest in heart failure patients admitted in January, on Friday, and overnight, according to research presented today at the Heart Failure Congress 2013. The analysis of nearly 1 million ...
12 hours ago | not rated yet | 0
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
12 hours ago | not rated yet | 0