Myogenes identified for spondyloarthritis synovitis

Myogenes identified for spondyloarthritis synovitis
There are disease-specific and inflammation-independent stromal alterations in spondyloarthritis synovitis, according to a study published online Sept. 12 in Arthritis & Rheumatism.

(HealthDay)—There are disease-specific and inflammation-independent stromal alterations in spondyloarthritis (SpA) synovitis, according to a study published online Sept. 12 in Arthritis & Rheumatism.

Nataliya Yeremenko, Ph.D., from the University of Amsterdam, and colleagues conducted a synovial gene expression analysis. Pan-genomic microarray (with confirmation by quantitative polymerase chain reaction and immunohistochemistry) was used to analyze synovial tissue biopsies from patients with SpA (63), RA (28), and gout (nine). By stimulating fibroblast-like synoviocytes with synovial fluid and analyzing synovial tissue samples at week zero and 12 of treatment with etanercept, the effect of inflammation on gene expression was evaluated.

The researchers found that microarray analysis identified 64 upregulated transcripts in SpA versus RA synovitis, with a robust myogene signature in this gene set. The myogene signature was specific for SpA and was independent of disease duration, treatment, and SpA subtype. Using synovial staining, the myogene expressing cells were identified as vimentin(+), 4-prolyl-hydroxylase-β(+), CD90(+) and CD146(+) mesenchymal cells. These were significantly overrepresented in the intimal lining layer and synovial sublining of inflamed SpA synovium.

"These data identify a novel and disease-specific myogene signature in SpA synovitis," Yeremenko and colleagues conclude. "The fact that this stromal alteration appeared not to be downstream of local warrants further analysis of its functional role in the disease pathogenesis."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Chlamydia may play role in a type of arthritis

Apr 30, 2009

Spondylarthritis (SpA) represents a group of arthritidies that share clinical features such as inflammatory back pain and inflammation at sites where tendons attach to bone. It includes ankylosing spondylitis (AS), psoriatic ...

Recommended for you

Drink milk? Women who do may delay knee osteoarthritis

Apr 07, 2014

New research reports that women who frequently consume fat-free or low-fat milk may delay the progression of osteoarthritis (OA) of the knee. Results published in the American College of Rheumatology (ACR) ...

Finger length a 'pointer' to Osteoarthritis

Mar 31, 2014

(Medical Xpress)—Our fingers could be more important than we think. New research has revealed that the length of a person's finger could become a 'pointer' to their risk factor in developing osteoarthritis ...

User comments