Neurocognitive deficits seen in survivors of pediatric Hodgkin's

Neurocognitive deficits seen in survivors of pediatric hodgkin's
Adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, according to research published online Sept. 4 in the Journal of Clinical Oncology.

(HealthDay)—Adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, according to research published online Sept. 4 in the Journal of Clinical Oncology.

To evaluate neurocognitive and brain imaging outcomes in adult survivors of childhood Hodgkin's lymphoma, Kevin R. Krull, Ph.D., of the St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues conducted a study involving 62 adult survivors who had been treated with either high- or low-dose thoracic radiation plus anthracycline.

The researchers found that Hodgkin's lymphoma survivors had significantly lower performance on tests of sustained attention, short- and long-term memory, working memory, naming speed, and cognitive fluency, compared with national age-adjusted norms. Fifty-three percent had leukoencephalopathy and 37 percent displayed evidence of cerebrovascular injury on . High-dose thoracic radiation was significantly associated with impaired cardiac diastolic and pulmonary function and leukoencephalopathy, compared to low-. Working memory impairment correlated with cardiac , while impaired sustained attention and naming speed correlated with pulmonary function. There was a correlation between neurocognitive performance and academic and vocational functioning.

"These results suggest that adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, which is associated with radiologic indices suggestive of reduced brain integrity and which occurs in the presence of symptoms of cardiopulmonary dysfunction," Krull and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Childhood cancer survivors at risk for cardiac events

Apr 04, 2012

(HealthDay) -- Childhood cancer survivors (CCSs) treated with anthracyclines and/or cardiac irradiation have a higher risk of developing symptomatic cardiac events (CEs) in the long term, according to a study ...

Recommended for you

Immune checkpoint inhibitors may work in brain cancers

Nov 21, 2014

New evidence that immune checkpoint inhibitors may work in glioblastoma and brain metastases was presented today by Dr Anna Sophie Berghoff at the ESMO Symposium on Immuno-Oncology 2014 in Geneva, Switzerland.

New model of follow up for breast cancer patients

Nov 21, 2014

Public health researchers from the University of Adelaide have evaluated international breast cancer guidelines, finding that there is potential to improve surveillance of breast cancer survivors from both a patient and health ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.