Neurocognitive deficits seen in survivors of pediatric Hodgkin's

Neurocognitive deficits seen in survivors of pediatric hodgkin's
Adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, according to research published online Sept. 4 in the Journal of Clinical Oncology.

(HealthDay)—Adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, according to research published online Sept. 4 in the Journal of Clinical Oncology.

To evaluate neurocognitive and brain imaging outcomes in adult survivors of childhood Hodgkin's lymphoma, Kevin R. Krull, Ph.D., of the St. Jude Children's Research Hospital in Memphis, Tenn., and colleagues conducted a study involving 62 adult survivors who had been treated with either high- or low-dose thoracic radiation plus anthracycline.

The researchers found that Hodgkin's lymphoma survivors had significantly lower performance on tests of sustained attention, short- and long-term memory, working memory, naming speed, and cognitive fluency, compared with national age-adjusted norms. Fifty-three percent had leukoencephalopathy and 37 percent displayed evidence of cerebrovascular injury on . High-dose thoracic radiation was significantly associated with impaired cardiac diastolic and pulmonary function and leukoencephalopathy, compared to low-. Working memory impairment correlated with cardiac , while impaired sustained attention and naming speed correlated with pulmonary function. There was a correlation between neurocognitive performance and academic and vocational functioning.

"These results suggest that adult long-term survivors of childhood Hodgkin's lymphoma are at risk for neurocognitive impairment, which is associated with radiologic indices suggestive of reduced brain integrity and which occurs in the presence of symptoms of cardiopulmonary dysfunction," Krull and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Childhood cancer survivors at risk for cardiac events

Apr 04, 2012

(HealthDay) -- Childhood cancer survivors (CCSs) treated with anthracyclines and/or cardiac irradiation have a higher risk of developing symptomatic cardiac events (CEs) in the long term, according to a study ...

Recommended for you

Early hormone therapy may be safe for women's hearts

2 hours ago

(HealthDay)—Healthy women at low risk of cardiovascular disease may be able to take hormone replacement therapy soon after menopause for a short time without harming their hearts, according to a new study.

Low yield for repeat colonoscopy in some patients

3 hours ago

(HealthDay)—Repeat colonoscopies within 10 years are of little benefit to patients who had no polyps found on adequate examination; however, repeat colonoscopies do benefit patients when the baseline examination was compromised, ...

Cell's recycling center implicated in division decisions

6 hours ago

Most cells do not divide unless there is enough oxygen present to support their offspring, but certain cancer cells and other cell types circumvent this rule. Researchers at The Johns Hopkins University have now identified ...

User comments