Pediatric kidney disease tied to abnormal carotid arteries

Pediatric kidney disease tied to abnormal carotid arteries
Ultrasound measurements of carotid intima-media thickness are significantly elevated among children with chronic kidney disease compared with healthy controls, according to a study published online Sept. 13 in the Clinical Journal of the American Society of Nephrology.

(HealthDay)—Ultrasound measurements of carotid intima-media thickness (cIMT) are significantly elevated among children with chronic kidney disease (CKD) compared with healthy controls, according to a study published online Sept. 13 in the Clinical Journal of the American Society of Nephrology.

Tammy M. Brady, M.D., from Johns Hopkins University in Baltimore, and colleagues analyzed data from 101 children aged 2 to 18 years with mild-to-moderate CKD (median [GFR], 42.9 ml/min/1.73 m²) enrolled in the in Children cohort study and 97 healthy controls followed for 12 months. Overall cIMT measurement was calculated from an average of six standardized B-mode ultrasound measurements.

The researchers found that median cIMT in children with CKD was 0.43 mm (interquartile range, 0.38 to 0.48), which was significantly greater than that in healthy controls (0.41 mm) and remained larger after multivariable adjustment. Dyslipidemia and hypertension were associated with 0.05 mm (95 percent confidence interval [CI], 0.01 to 0.08) and 0.04 mm (95 percent CI, 0.003 to 0.08) greater mean cIMT, respectively. cIMT was not associated with , CKD etiology, GFR, birth weight, pubertal status, calcium, phosphorus, sex, or race.

"cIMT is significantly elevated among children with CKD, as is the prevalence of other ," the authors write. "Of these risk factors, hypertension and dyslipidemia are significantly associated with increased cIMT."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Ebola: Keeping patients alive as body fights back

8 hours ago

People who shared an apartment with the first U.S. Ebola patient are emerging from quarantine healthy. And while Thomas Eric Duncan died and two U.S. nurses were infected caring for him, there are successes, ...

Study suggests altering gut bacteria might mitigate lupus

9 hours ago

Lactobacillus species, commonly seen in yogurt cultures, correlate, in the guts of mouse models, with mitigation of lupus symptoms, while Lachnospiraceae, a type of Clostridia, correlate with worsening, according to researc ...

User comments