Pediatric kidney disease tied to abnormal carotid arteries

September 28, 2012
Pediatric kidney disease tied to abnormal carotid arteries
Ultrasound measurements of carotid intima-media thickness are significantly elevated among children with chronic kidney disease compared with healthy controls, according to a study published online Sept. 13 in the Clinical Journal of the American Society of Nephrology.

(HealthDay)—Ultrasound measurements of carotid intima-media thickness (cIMT) are significantly elevated among children with chronic kidney disease (CKD) compared with healthy controls, according to a study published online Sept. 13 in the Clinical Journal of the American Society of Nephrology.

Tammy M. Brady, M.D., from Johns Hopkins University in Baltimore, and colleagues analyzed data from 101 children aged 2 to 18 years with mild-to-moderate CKD (median [GFR], 42.9 ml/min/1.73 m²) enrolled in the in Children cohort study and 97 healthy controls followed for 12 months. Overall cIMT measurement was calculated from an average of six standardized B-mode ultrasound measurements.

The researchers found that median cIMT in children with CKD was 0.43 mm (interquartile range, 0.38 to 0.48), which was significantly greater than that in healthy controls (0.41 mm) and remained larger after multivariable adjustment. Dyslipidemia and hypertension were associated with 0.05 mm (95 percent confidence interval [CI], 0.01 to 0.08) and 0.04 mm (95 percent CI, 0.003 to 0.08) greater mean cIMT, respectively. cIMT was not associated with , CKD etiology, GFR, birth weight, pubertal status, calcium, phosphorus, sex, or race.

"cIMT is significantly elevated among children with CKD, as is the prevalence of other ," the authors write. "Of these risk factors, hypertension and dyslipidemia are significantly associated with increased cIMT."

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Recommended for you

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.