Prenatal maternal smoking associated with increased risk of adolescent obesity

September 3, 2012

Prenatal exposure to maternal cigarette smoking appears associated with an increased risk for adolescent obesity, and is possibly related to subtle structural variations in the brain that create a preference for eating fatty foods, according to a report published Online First by Archives of General Psychiatry.

"Prenatal exposure to maternal cigarette smoking is a well-established risk factor for obesity, but the underlying mechanisms are not known," the authors write as background information. "Preference for fatty foods, regulated in part by the system, may contribute to the development of obesity."

Amirreza Haghighi, M.D., of the Hospital for Sick Children, Toronto, Canada, and colleagues, studied 378 adolescents age 13 to 19 years who were recruited through high schools in one region of Quebec, Canada, as part of the ongoing Saguenay Youth Study. Participants were grouped as exposed to maternal smoking (n=180) or nonexposed to maternal smoking (n=198) and participants in each group were matched at recruitment by and participant's to minimize confounding influence of socioeconomic status (SES), and did not differ by sex, age, puberty stage or height.

The authors defined exposed as having a mother who smoked more than one cigarette a day during the second trimester of pregnancy, and nonexposed as having a mother who did not smoke one year before (and throughout) the pregnancy.

Exposed versus nonexposed participants weighed less at birth and were breastfed for shorter periods of time. At the time of analysis, exposed participants had a marginally higher body weight and BMI, and a significantly higher total body fat compared with nonexposed participants. These differences persisted after adjustment for age, sex, and height (when appropriate), and were still significant when adjusting for additional variables frequently associated with maternal (i.e., lower birth weight, shorter duration [or lack of] breastfeeding, and lower SES).

Exposed versus nonexposed participants also exhibited a significantly lower volume of the amygdala (part of the brain that plays a role in processing emotions and storing memories), and the authors found that, consistent with its possible role in limiting fat intake, amygdala volume correlated inversely with fat intake.

"Prenatal exposure to maternal cigarette smoking may promote obesity by enhancing dietary preference for fat, and this effect may be mediated in part through subtle structural variations in the amygdala," the authors conclude.

Explore further: Smoking during pregnancy lowers levels of 'good' HDL cholesterol in children

More information: Arch Gen Psychiatry. Published online September 3, 2012. doi:10.1001/archgenpsychiatry.2012.1101

Related Stories

Pre-pregnancy BMI important indicator of offspring obesity

April 17, 2012

(HealthDay) -- Maternal gestational weight gain (GWG) during the first 20 weeks of pregnancy correlates with body mass index (BMI)-based overweight/obesity and abdominal obesity at age 16, but maternal pre-pregnancy BMI is ...

Recommended for you

A metabolic master switch underlying human obesity

August 19, 2015

Obesity is one of the biggest public health challenges of the 21st century. Affecting more than 500 million people worldwide, obesity costs at least $200 billion each year in the United States alone, and contributes to potentially ...

Scientists probe obesity's ties to breast cancer risk

August 20, 2015

Obesity is a well-known risk factor for breast cancer, but researchers haven't figured out what connects the two. A new study suggests the link may be due to a change in breast tissue structure, which might promote breast ...

Can a new drug brown the fat and trim the obese person?

May 28, 2015

New research has found that a variant of a drug used to treat pulmonary arterial hypertension prompts weight loss in obese mice. Among mice fed a high-fat diet, those who did not get the medication became obese while medicated ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.