Sequential oral, topical tacrolimus benefits dermatitis

Sequential oral, topical tacrolimus benefits dermatitis
Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis, according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

(HealthDay)—Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis (AD), according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

To examine the safety and efficacy of sequential therapy with oral and topical tacrolimus, Terrence Colin Keaney, M.D., from the University of Miami, and colleagues enrolled 12 patients with AD covering at least 50 percent of their body. Over a 14-week period, patients received sequential therapy with oral and topical tacrolimus. At each study visit, the Eczema Area and Severity Index, Physician Global Assessment, and pruritus scores were measured.

The researchers found that, in the Eczema Area and Severity Index score, patients recorded a 67 percent improvement. In the Physician Global Assessment there was a 45 percent improvement recorded, and in the pruritus score a 69 percent reduction was noted.

"In this , treatment of severe AD with oral tacrolimus succeeded in providing quick disease control followed by a successful smooth transition to maintenance with topical tacrolimus 0.1 percent ointment," the authors write.

Two authors disclosed to pharmaceutical companies, including Astellas Pharma, which funded the study.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Topical treatment shows potential for infantile eczema

Aug 08, 2012

(HealthDay) -- Ten days of treatment with a cream containing 15(R/S)-methyl-lipoxin A4 (LXA4) is well tolerated and reduces the severity of infantile eczema, according to a study published online July 26 in the ...

Azathioprine may benefit pediatric atopic dermatitis

Aug 21, 2012

(HealthDay) -- For pediatric patients with refractory atopic dermatitis (AD), oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase (TPMT) activity seems ...

Recommended for you

Restrictions lifted at British bird flu farm

3 hours ago

Britain on Sunday lifted all restrictions at a duck farm in northern England after last month's outbreak of H5N8 bird flu, the same strain seen in recent cases across Europe.

Recorded Ebola deaths top 7,000

Dec 20, 2014

The worst Ebola outbreak on record has now killed more than 7,000 people, with many of the latest deaths reported in Sierra Leone, the World Health Organization said as United Nations Secretary-General Ban ...

Liberia holds Senate vote amid Ebola fears (Update)

Dec 20, 2014

Health workers manned polling stations across Liberia on Saturday as voters cast their ballots in a twice-delayed Senate election that has been criticized for its potential to spread the deadly Ebola disease.

Evidence-based recs issued for systemic care in psoriasis

Dec 19, 2014

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.