Sequential oral, topical tacrolimus benefits dermatitis

September 20, 2012
Sequential oral, topical tacrolimus benefits dermatitis
Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis, according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

(HealthDay)—Sequential therapy with oral tacrolimus and topical tacrolimus may be an effective treatment for severe atopic dermatitis (AD), according to a pilot study published in the October issue of the Journal of the American Academy of Dermatology.

To examine the safety and efficacy of sequential therapy with oral and topical tacrolimus, Terrence Colin Keaney, M.D., from the University of Miami, and colleagues enrolled 12 patients with AD covering at least 50 percent of their body. Over a 14-week period, patients received sequential therapy with oral and topical tacrolimus. At each study visit, the Eczema Area and Severity Index, Physician Global Assessment, and pruritus scores were measured.

The researchers found that, in the Eczema Area and Severity Index score, patients recorded a 67 percent improvement. In the Physician Global Assessment there was a 45 percent improvement recorded, and in the pruritus score a 69 percent reduction was noted.

"In this , treatment of severe AD with oral tacrolimus succeeded in providing quick disease control followed by a successful smooth transition to maintenance with topical tacrolimus 0.1 percent ointment," the authors write.

Two authors disclosed to pharmaceutical companies, including Astellas Pharma, which funded the study.

Explore further: Best post-transplant drug regimen identified for patients with new kidneys

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Topical treatment shows potential for infantile eczema

August 8, 2012

(HealthDay) -- Ten days of treatment with a cream containing 15(R/S)-methyl-lipoxin A4 (LXA4) is well tolerated and reduces the severity of infantile eczema, according to a study published online July 26 in the British Journal ...

Azathioprine may benefit pediatric atopic dermatitis

August 21, 2012

(HealthDay) -- For pediatric patients with refractory atopic dermatitis (AD), oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase (TPMT) activity seems useful for monitoring ...

Recommended for you

Cellphone data can track infectious diseases

August 20, 2015

Tracking mobile phone data is often associated with privacy issues, but these vast datasets could be the key to understanding how infectious diseases are spread seasonally, according to a study published in the Proceedings ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.