Study supports tobacco link to ovarian cancer
A major outcome was evidence to support smoking’s link to the disease, which until recently had not been considered a risk factor. Image: Micke Jakobsson
(Medical Xpress)—Researchers from Curtin University's School of Public Health have contributed to a comprehensive international study examining risk factors for ovarian cancer.
Their work involved the completion of two studies in China, which were fed into a pool of data totalling 28,114 women with, and 94,942 women without, ovarian cancer.
The aim of the project was to gather and analyse epidemiological evidence from published and unpublished sources which could shed light on the second most commonly diagnosed gynaecological cancer in Australia, one which Cancer Australia lists as having a five-year survival rate of only 40 per cent.
A major outcome was evidence to support smoking's link to the disease, which until recently had not been considered a risk factor.
"Previously there was only a weak link between smoking and ovarian cancer, coming from a paper in 2009. This new analysis firmly establishes that relationship for one particular type of ovarian cancer, mucinoid tumours, which account for about 15 per cent of the total of all ovarian cancers," Prof Binns says.
Interestingly, increased smoking-related occurrences of mucinoid tumours showed up primarily in borderline malignant tumours with no significant association with those fully malignant. Occurrences of other types of ovarian cancers showed no significant differences between current smokers and those how had never lit up.
Outcomes were consistent along 13 socio-demographic and personal characteristics which were taken into account, including body-mass index, use of alcohol, use of oral contraceptives and menopausal hormone therapy.
Prof Binns says more research was needed to understand how smoking stimulated the creation of mucinoid tumours, but stressed the first step in prevention was for women to quit cigarettes.
"While giving up smoking is the best advice, we did find evidence that drinking green tea, breastfeeding, eating fruit and vegetables, getting regular exercise and avoiding obesity were also beneficial," he says.
Prof Binns says the study was a step forward and reflected well the quality of work being done at Curtin University.
"We are very proud that the work of the School of Public Health is world class and can be included in this collaborative effort with other top universities from around the world," he says.
More information: 'Ovarian cancer and smoking: individual participant meta-analysis including 28,114 women with ovarian cancer from 51 epidemiological studies' appears in The Lancet Oncology volume 13, issue 9.
Journal reference: Lancet Oncology
Provided by Curtin University
- Study links obesity to elevated risk of ovarian cancer Jan 05, 2009 | not rated yet | 0
- Drinking tea may reduce ovarian cancer risk May 31, 2010 | not rated yet | 0
- Ovarian cancer risk not affected by alcohol and smoking, but reduced by caffeine Jan 22, 2008 | not rated yet | 0
- Ovarian stimulation for IVF treatment increases risk of borderline ovarian tumors later in life Oct 27, 2011 | not rated yet | 0
- Study links endometriosis with increased risk of developing 3 specific types of ovarian cancer Feb 21, 2012 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
Older prostate cancer patients with other underlying health conditions should think twice before committing to surgery or radiation therapy for their cancer, according to a multicenter study led by researchers in the UCLA ...
Cancer 8 hours ago | not rated yet | 0 |
Intensity-modulated radiation therapy has become the most commonly used type of radiation in prostate cancer, but research from the University of North Carolina suggests that the therapy may not be more effective than older, ...
Cancer 10 hours ago | not rated yet | 0
New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells' "superpower" to escape death. By altering a very specific step in gene regulation, this compound essentially re-educates cancer ...
Cancer 10 hours ago | 4.8 / 5 (11) | 2 |
(HealthDay)—For young adults needing either a chest or abdominopelvic computed tomography (CT), the short-term risk of death from underlying morbidity is greater than the long-term risk of radiation-induced ...
Cancer 11 hours ago | not rated yet | 0
In a new study described in the journal Oncogene, researchers reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.
Cancer 17 hours ago | not rated yet | 0 |
Early-life exposure to traffic-related air pollution was significantly associated with higher hyperactivity scores at age 7, according to new research from the University of Cincinnati (UC) and Cincinnati Children's Hospital ...
2 hours ago | not rated yet | 0 |
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
7 hours ago | 4.5 / 5 (11) | 2 |
Bacteria resistant to the antibiotic colistin are also commonly resistant to antimicrobial substances made by the human body, according to a study in mBio, the online open-access journal of the American Society for Microb ...
2 hours ago | 5 / 5 (1) | 0
Researchers have pinpointed a catalytic trigger for the onset of Alzheimer's disease – when the fundamental structure of a protein molecule changes to cause a chain reaction that leads to the death of neurons ...
11 hours ago | 5 / 5 (3) | 0 |
Salamanders' immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have ...
11 hours ago | 4.8 / 5 (6) | 2 |
Turns out, that old "practice makes perfect" adage may be overblown. New research led by Michigan State University's Zach Hambrick finds that a copious amount of practice is not enough to explain why people ...
8 hours ago | 3.3 / 5 (10) | 0 |