Biomarkers in cerebrospinal fluid can identify patients with Alzheimer's disease

Analysis of specific biomarkers in a cerebrospinal fluid sample can differentiate patients with Alzheimer's disease from those with other types of dementia. The method, which is being studied by researchers at Sahlgrenska Academy, may eventually permit earlier detection of Alzheimer's disease.

Due to the similarity of the symptoms, differentiating patients with Alzheimer's from those with other types of dementia – or patients with Parkinsondisease from those with other motor disorders – is often difficult.

Making a proper diagnosis is essential if proper treatment and medication are to commence at an early stage. A research team at Sahlgrenska Academy, University of Gothenburg, is developing a new method to differentiate patients with Alzheimer's disease or Parkinson disease by analyzing a sample.

The study, led by Professor Kaj Blennow and conducted among 450 patients at Skåne University Hospital and Sahlgrenska University Hospital, involved testing five proteins that serve as biomarkers for the two diseases.

"Previous studies have shown that Alzheimer's disease is associated with in specific proteins of the brain," says Annika Öhrfelt, a researcher at Sahlgrenska Academy. "This study has found that the inclusion of a new protein can differentiate patients with Alzheimer's disease from those with Lewy body dementia, Parkinson disease dementia and other types of ."

Similarly, the biomarkers can differentiate patients with from those with atypical Parkinsonian disorders.

"Additional studies are needed before the can be used in clinical practice during the early stages of disease," says Öhrfelt, "but these results represent an important step along the way."

More information: The article, entitled "Accuracy of a Panel of 5 Cerebrospinal Fluid Biomarkers in the Differential Diagnosis of Patients with Dementia and/or Parkinsonian Disorders," was published by the Journal of the American Medical Association. archneur.jamanetwork.com/artic… px?articleid=1355364

add to favorites email to friend print save as pdf

Related Stories

More accurate diagnosis of Alzheimer's

Apr 19, 2011

A new study from the University of Gothenburg, Sweden, shows how analysing spinal fluid can help to detect Alzheimer's disease at an early stage. The researchers behind the study hope that their findings will contribute to ...

CSF test can pick up Alzheimer's early

Dec 20, 2011

Analysis of the cerebrospinal fluid can detect whether a person has Alzheimer's disease before symptoms appear. Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden, have studied biomarkers that ...

Biological fingerprints improve diagnosis of dementia

Oct 04, 2011

Differentiating between the various forms of dementia is crucial for initiating appropriate treatment. Researchers at the Sahlgrenska Academy have discovered that the underlying diseases leave different "fingerprints" in ...

New clues to the cause of Alzheimer's disease

Jun 30, 2011

Researchers at the Sahlgrenska Academy, University of Gothenburg, have identified a series of novel proteins in human cerebrospinal fluid. The proteins, which carry specific sugar molecules, are found in greater concentrations ...

Recommended for you

Researchers identify potential biomarker for AD

Jul 28, 2014

Researchers from Boston University School of Medicine (BUSM) report variants in a new gene, PLXNA4, which may increase the risk of developing Alzheimer's disease (AD). The discovery of this novel genetic association may lead ...

Study links enzyme to Alzheimer's disease

Jul 21, 2014

Unclogging the body's protein disposal system may improve memory in patients with Alzheimer's disease (AD), according to a study from scientists at Kyungpook National University in Korea published in The Jo ...

User comments