Researchers discover way to save blood from ravages of chemo treatment

The image on the left is from a mouse that is normal. The image on the right is from a mouse treated with chemotherapy. The two blue cells are white blood cells; the red cells are red blood cells

(Medical Xpress)—Chemotherapy kills blood cells as well as cancer cells, often with fatal results. Now Yale stem cell researchers have identified a method they hope one day will help cancer patients undergoing chemotherapy maintain a healthy blood supply, they report in the Oct. 18 issue of the journal Cell Reports.

The team, under the direction of Jun Lu, assistant professor of genetics at the Yale Stem Cell Center and Yale Cancer Center, studies how blood cells regenerate. Lu is particularly interested in roles played by tiny bits of genetic material called microRNAs in the production of blood and the function of blood stem and progenitor cells, which help determine the type of blood cell created. Chemotherapy kills these types of , making it difficult for blood to regenerate. While can be replaced by transfusions, and platelets often do not recover well, leaving cancer patients prone to infections and bleeding.

Using a novel technique to analyze simultaneously large numbers of microRNAs in living mice, the researchers identified several that are involved in blood formation. When they disabled one of these microRNAs, miR-150, they found that mice were able to more efficiently regenerate white cells and platelets depleted by chemotherapy. Mice without this microRNA showed no ill health effects. Conversely, mice with active miR-150 had difficulty generating new blood cells.

"We hope that finding specific microRNAs involved in blood formation will provide us ways not only to help cancer patients survive chemotherapy, but to make chemotherapy more efficient," Lu said.

add to favorites email to friend print save as pdf

Related Stories

Fish oil reduces effectiveness of chemotherapy

Sep 12, 2011

Researchers at University Medical Center Utrecht, the Netherlands, have discovered a substance that has an adverse effect on nearly all types of chemotherapy - making cancer cells insensitive to the treatment. Chemotherapy ...

Recommended for you

Stem cells faulty in Duchenne muscular dystrophy

23 hours ago

Like human patients, mice with a form of Duchenne muscular dystrophy undergo progressive muscle degeneration and accumulate connective tissue as they age. Now, researchers at the Stanford University School of Medicine have ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.