Common birth control device may be cost-effective treatment for early endometrial cancer

An intrauterine device is effective in treating early-stage endometrial cancer in morbidly obese and high-risk surgery patients, said Dr. Sharad Ghamande, a gynecologic surgeon and oncologist at the GHSU Cancer Center, Chief of the Section of Gynecologic Oncology at the Medical College of Georgia, and principal investigator on the study, and could lead to a cost-effective treatment for all women with this cancer type. Credit: Phil Jones

A common birth control device is effective in treating early-stage endometrial cancer in morbidly obese and high-risk surgery patients, said Georgia Health Sciences University Cancer Center researchers, and could lead to a cost-effective treatment for all women with this cancer type.

Endometrial , which starts in the , is the third most common gynecologic cancer, striking more than 47,000 American women every year, particularly the obese. "Total hysterectomy, sometimes with removal of lymph nodes, is the most common treatment for this type of cancer. But women who are morbidly obese or who have are not good candidates for surgery," said Dr. Sharad Ghamande, a gynecologic surgeon and oncologist at the GHSU Cancer Center, Chief of the Section of Gynecologic Oncology at the Medical College of Georgia, and principal investigator on the study.

For two years, Ghamande and his team followed a small group of high-risk patients with early-stage endometrioid adenocarcinoma, a common subtype of endometrial cancer, and those with atypical endometrial hyperplasia, or thickening of the uterine lining, which can lead to cancer. Patients were treated with an intrauterine device that releases the progestin levonorgestrel, successfully used for the past decade as a contraceptive.

The endometrial stripe, or thickness of the endometrium, was measured with transvaginal ultrasound before the study and at the three- and six-month marks. The stripe's progressive thinning at each stage demonstrated the effectiveness of the treatment. Subsequent endometrial biopsy found reversal of abnormal cell growth, known as neoplastic changes, in all patients.

Ghamande's group also analyzed 13 published studies and found a complete pathological response in 91.3 percent of cases, with no progression of disease, confirming their findings. The study also validated use of transvaginal ultrasound, commonly used to diagnose endometrial cancer, as a useful follow-up tool in assessing endometrial cancer treatment.

"Thirty to 35 percent of women with hyperplasia will go on to develop , and in 30 percent of these cases, women will present with a co-existing cancer," said Ghamande. "Traditional treatments can result in postoperative complications and morbidity, not only in patients at high risk. But we may succeed in establishing a lower-risk and more cost-effective way of managing this cancer in all women."

"Identifying better treatments for cancer is the most important goal of our cancer research center," said Dr. Samir N. Khleif, Director of the GHSU Cancer Center. "Studies such as Dr. Ghamande's are changing the landscape of cancer care today, both here in Georgia and around the world."

Ghamande and Dr. Cinar Aksu, a GHSU Cancer Center fellow, presented the study results on Tuesday during the International Gynecological Cancer Society's 14th biennial meeting. Dr. Michael Mcfee, a gynecologic oncologist, and fellow Dr. Steve Bush, both of the GHSU Cancer Center, co-authored the study.

add to favorites email to friend print save as pdf

Related Stories

Women's cancer outcomes improved by surgical evaluation

Feb 12, 2009

Many women scheduled to undergo hysterectomy for pre-cancerous cell changes actually need a more comprehensive surgery, something they should discuss with a gynecologic oncologist, say researchers at the University of Alabama ...

Recommended for you

Pepper and halt: Spicy chemical may inhibit gut tumors

9 hours ago

Researchers at the University of California, San Diego School of Medicine report that dietary capsaicin – the active ingredient in chili peppers – produces chronic activation of a receptor on cells lining ...

Expressive writing may help breast cancer survivors

11 hours ago

Writing down fears, emotions and the benefits of a cancer diagnosis may improve health outcomes for Asian-American breast cancer survivors, according to a study conducted by a researcher at the University of Houston (UH).

Taking the guesswork out of cancer therapy

17 hours ago

Researchers and doctors at the Institute of Bioengineering and Nanotechnology (IBN), Singapore General Hospital (SGH) and National Cancer Centre Singapore (NCCS) have co-developed the first molecular test ...

Brain tumour cells found circulating in blood

18 hours ago

(Medical Xpress)—German scientists have discovered rogue brain tumour cells in patient blood samples, challenging the idea that this type of cancer doesn't generally spread beyond the brain.

International charge on new radiation treatment for cancer

18 hours ago

(Medical Xpress)—Imagine a targeted radiation therapy for cancer that could pinpoint and blast away tumors more effectively than traditional methods, with fewer side effects and less damage to surrounding tissues and organs.

User comments