New discovery to improve success rates of IVF

(Medical Xpress)—Researchers from the University of Otago, Christchurch, are collaborating with clinicians at Fertility Associates in Christchurch to develop a test to significantly improve the success rate for in vitro fertilisations implantations.

Christchurch researcher, Dr Gloria Evans, has just published a paper in the international journal which shows positive results for a test to determine the optimal time to implant a fertilised embryo through IVF.

She has discovered for the first time key biomarkers – or signs - which show when a woman's uterus is 'more favourable' for implantation. If the key biomarkers are not present, then the embryo can be frozen until a cycle with more positive can be achieved.

This discovery could have a significant effect in improving the success rate for couples undergoing the emotional and expensive process of IVF.

In collaboration with Fertility Associates Christchurch, Dr Evans now wants to confirm her exciting findings in a larger sample of women and is calling for volunteers.

Evans says currently less than half of fertilised eggs implanted through IVF result in a pregnancy.

Implantation failure, where the woman's uterus is not in an optimal state to receive a fertilised embryo, is a common reason for IVF failing.

A woman might be taking and be but pregnancy does not occur.

"The main problem at present is there is a lack of understanding of events at the time the embryo is implanted into the uterus (the window of implantation).

Researchers have been exploring this challenge for some time but have not been able to develop a showing how 'hospitable' the uterus is to implantation.

What Dr Evans has determined for the first time is a showing when the uterus is more hospitable for implantation. She and Fertility Associates Christchurch medical director Dr Greg Phillipson will now confirm these findings in a larger sample of women undergoing IVF treatment and fine-tune the test for use in IVF clinics.

"This test will mean that clinicians may be able to determine the best time in the fertility cycle to implant embryos giving women a much better chance of achieving pregnancy."

"If these very encouraging results are supported in this expanded study it would mean a big step forward in assisting couples who are going through the IVF process to try to have a child."

The larger study requires women volunteers from Christchurch, Auckland, Wellington and Hamilton to take a simple test involving a minute sample of tissue from the endometrium or lining of the uterus.

More information: Dr Evans says the research team would be grateful if any woman aged 20 – 37 years who has experienced unexplained repeat miscarriage or IVF procedures without pregnancy occurring or women who require treatment for poor ovulation could contact Fertility Associates 0800102828 or gloria.evans@otago.ac.nz to find out more details about taking part in this ground-breaking study.

add to favorites email to friend print save as pdf

Related Stories

Engineering bouncing babies, one at a time

Mar 02, 2009

As hopeful moms-to-be learn, there are important considerations to the successful implantation of a fertilized human egg. A calm environment, regular hormonal injections and the timing of the implantation can all affect the ...

Baby born from embryo frozen almost 20 years ago

Oct 12, 2010

(PhysOrg.com) -- A healthy baby has been born from an embryo that was kept frozen for nearly 20 years, smashing the previous record of 13 years. The new baby is a biological sibling of a child born to the ...

Recommended for you

Cinnamon may improve menstrual cyclicity in PCOS

13 hours ago

(HealthDay)—For women with polycystic ovary syndrome (PCOS), cinnamon supplements may improve menstrual cyclicity, according to a study published in the November issue of the American Journal of Obstetrics & ...

Vitamin D may not prevent return of vaginosis after all

Oct 29, 2014

(HealthDay)—A new study suggests that high doses of vitamin D may not help prevent the return of bacterial vaginosis (BV). The research was published in the November issue of the American Journal of Obstetrics and Gynecology.

Eating disorders linked to adverse perinatal outcomes

Oct 22, 2014

(HealthDay)—Maternal eating disorders are associated with adverse pregnancy, obstetric, and perinatal health outcomes, according to a study published in the October issue of the American Journal of Obstetrics & ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.