Exposure to traffic air pollution in infancy impairs lung function in children

Exposure to ambient air pollution from traffic during infancy is associated with lung function deficits in children up to eight years of age, particularly among children sensitized to common allergens, according to a new study.

"Earlier studies have shown that children are highly susceptible to the adverse effects of air pollution and suggest that exposure early in life may be particularly harmful," said researcher Göran Pershagen, MD, PhD, professor at the Karolinska Institutet Institute of in Stockholm, Sweden. "In our prospective study in a large population of Swedish children, exposure to traffic-related air pollution during infancy was associated with decreases in lung function at age eight, with stronger effects indicated in boys, children with asthma and particularly in children sensitized to allergens."

The findings were published online ahead of print publication in the 's American Journal of Respiratory and .

The study included more than 1,900 children who were followed from birth through age eight with repeated questionnaires, spirometry and immunoglobulin E measurements. Outdoor concentrations of particulate matter from road traffic were estimated for residential, daycare and school addresses using dispersion modeling, a of how air pollutants disperse in the atmosphere.

A 5th to 95th percentile difference in time-weighted exposure to outdoor concentrations of particulate matter from road traffic during the first year of life was associated with a reduced forced expiratory volume in one second (FEV1) of -59.3 mL (95% confidence interval (CI): -113.0 to -5.6) at age eight. This negative association was particularly pronounced in children who were sensitized to common inhalant and/or food allergens and also seemed stronger among boys and among children with asthma.

Exposure to traffic-related air pollution after the first year of life appeared to have less impact on subsequent lung function.

The study had a few limitations. Calculations of particulate matter concentrations were only performed for the year 2004 and were extrapolated to the other years of follow-up, and some miscalculation of individual exposure levels was likely.

"Our study shows that early exposure to traffic-related air pollution has long-term adverse effects on respiratory health in children, particularly among atopic children," concluded Dr. Pershagen. "These results add to a large body of evidence demonstrating the detrimental effects of on human health."

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