Gastro illness in infancy linked to islet autoimmunity

Gastro illness in infancy linked to islet autoimmunity
Gastrointestinal illnesses are associated with increased risk of islet autoimmunity among children who are exposed to wheat or barley either early or late in infancy, according to a study published online Oct. 5 in Diabetes Care.

(HealthDay)—Gastrointestinal illnesses are associated with increased risk of islet autoimmunity (IA) among children who are exposed to wheat or barley either early or late in infancy, according to a study published online Oct. 5 in Diabetes Care.

Janet K. Snell-Bergeon, Ph.D., M.P.H., from the University of Colorado Anschutz Medical Campus in Aurora, and colleagues examined the association of reported illness during infancy and later development of IA using data from illness interviews though 9 months of age, collected for 1,729 children (1,174 without a family history of type 1 diabetes and 555 children with a first-degree relative with ). Having positive antibodies to insulin, , or tyrosine phosphatase on at least two consecutive study visits was defined as persistent IA.

The researchers found that 109 children had persistent IA. There was a significantly increased risk of IA associated with greater number of gastrointestinal illnesses, but only among children who were exposed to gluten-containing grains (wheat or barley) either at younger than 4 months of age (hazard ratio, 1.37) or at 7 months of age or older (hazard ratio, 1.12). Upper respiratory symptoms, , or fevers were not associated with an increased risk of IA.

"Specific pathogens such as enteroviruses or rotavirus may increase the risk of IA in the presence of existing inflammation induced by diet," Snell-Bergeon and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Childhood famine increases risk of type 2 diabetes

Jun 05, 2012

(HealthDay) -- Even a short period of moderate or severe undernutrition or famine during childhood or adolescence can increase the risk of developing type 2 diabetes in adulthood, according to research published ...

In Taiwan, diabetes linked to increased Parkinson's risk

Apr 02, 2012

(HealthDay) -- Individuals with diabetes in Taiwan have a significantly increased risk of Parkinson's disease (PD), which is robust across most age and gender stratifications, according to a study published ...

G299.2-2.9, a middle-aged supernova remnant

Oct 13, 2011

(PhysOrg.com) -- G299.2-2.9 is an intriguing supernova remnant found about 16,000 light years away in the Milky Way galaxy. Evidence points to G299.2-2.9 being the remains of a Type Ia supernova, where a white ...

Recommended for you

Low-carb diet recommended for diabetics

Jul 29, 2014

A new study involving researchers from the University of Alabama at Birmingham and other institutions says patients with Type 1 and Type 2 diabetes should eat a diet low in carbohydrates.

Shift work linked to heightened risk of type 2 diabetes

Jul 24, 2014

Shift work is linked to a heightened risk of developing type 2 diabetes, with the risk seemingly greatest among men and those working rotating shift patterns, indicates an analysis of the available evidence published online ...

Rosemary and oregano contain diabetes-fighting compounds

Jul 23, 2014

The popular culinary herbs oregano and rosemary are packed with healthful compounds, and now lab tests show they could work in much the same way as prescription anti-diabetic medication, scientists report. In their new study ...

User comments