Gastro illness in infancy linked to islet autoimmunity

Gastro illness in infancy linked to islet autoimmunity
Gastrointestinal illnesses are associated with increased risk of islet autoimmunity among children who are exposed to wheat or barley either early or late in infancy, according to a study published online Oct. 5 in Diabetes Care.

(HealthDay)—Gastrointestinal illnesses are associated with increased risk of islet autoimmunity (IA) among children who are exposed to wheat or barley either early or late in infancy, according to a study published online Oct. 5 in Diabetes Care.

Janet K. Snell-Bergeon, Ph.D., M.P.H., from the University of Colorado Anschutz Medical Campus in Aurora, and colleagues examined the association of reported illness during infancy and later development of IA using data from illness interviews though 9 months of age, collected for 1,729 children (1,174 without a family history of type 1 diabetes and 555 children with a first-degree relative with ). Having positive antibodies to insulin, , or tyrosine phosphatase on at least two consecutive study visits was defined as persistent IA.

The researchers found that 109 children had persistent IA. There was a significantly increased risk of IA associated with greater number of gastrointestinal illnesses, but only among children who were exposed to gluten-containing grains (wheat or barley) either at younger than 4 months of age (hazard ratio, 1.37) or at 7 months of age or older (hazard ratio, 1.12). Upper respiratory symptoms, , or fevers were not associated with an increased risk of IA.

"Specific pathogens such as enteroviruses or rotavirus may increase the risk of IA in the presence of existing inflammation induced by diet," Snell-Bergeon and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Childhood famine increases risk of type 2 diabetes

Jun 05, 2012

(HealthDay) -- Even a short period of moderate or severe undernutrition or famine during childhood or adolescence can increase the risk of developing type 2 diabetes in adulthood, according to research published ...

In Taiwan, diabetes linked to increased Parkinson's risk

Apr 02, 2012

(HealthDay) -- Individuals with diabetes in Taiwan have a significantly increased risk of Parkinson's disease (PD), which is robust across most age and gender stratifications, according to a study published ...

G299.2-2.9, a middle-aged supernova remnant

Oct 13, 2011

(PhysOrg.com) -- G299.2-2.9 is an intriguing supernova remnant found about 16,000 light years away in the Milky Way galaxy. Evidence points to G299.2-2.9 being the remains of a Type Ia supernova, where a white ...

Recommended for you

Economic burden of prediabetes up 74 percent over five years

Nov 20, 2014

The economic burden of diabetes in America continues to climb, exceeding more than $322 billion in excess medical costs and lost productivity in 2012, or more than $1,000 for every American, according to a study being published ...

Gynoid fat resists metabolic risks of obesity

Nov 19, 2014

(HealthDay)—The differences in the developmental profiles of upper-body and lower-body fat depots may explain their opposing associations with obesity-related metabolic disease, according to research published ...

Treating diabetes one meal at a time

Nov 19, 2014

Recent estimates project that as many as one in three American adults will have diabetes in 2050. The American Diabetes Association observes November as American Diabetes Month, and this year's theme is America ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.