Genetic predisposition to diabetes ups risk of CVD

Genetic predisposition to diabetes ups risk of CVD
For patients with type 2 diabetes, having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease, according to a study published online Oct. 15 in Diabetes Care.

(HealthDay)—For patients with type 2 diabetes (T2D), having a genetic predisposition towards the disease is associated with an increased risk of cardiovascular disease (CVD), according to a study published online Oct. 15 in Diabetes Care.

Qibin Qi, Ph.D., from the Harvard School of Public Health in Boston, and colleagues analyzed data from 1,012 men and 1,310 women with T2D from the Health Professionals Follow-up Study and Nurses' Health Study, including 677 with CVD and 1,645 control subjects without CVD. On the basis of 36 established independent diabetes-predisposing variants, a genetic predisposition score (GPS) was calculated.

The researchers found that each additional diabetes-risk allele in the GPS correlated with a 3 percent elevated risk of CVD (odds ratio [OR], 1.03; 95 percent confidence interval, 1.00 to 1.06). By comparing extreme quartiles of the GPS, the OR was 1.47 for CVD risk (P for trend = 0.01). There was a significant positive association for GPS with hemoglobin A1c levels.

"In conclusion, we found that the genetic predisposition to T2D was significantly associated with an increased risk of CVD in patients with T2D," the authors write. "Further studies are needed to examine the relationship among the to T2D, glycemic control, and CVD."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

NAFLD independently linked to cardiovascular disease

Jun 07, 2012

(HealthDay) -- Nonalcoholic fatty liver disease (NAFLD) is independently associated with an increased risk of cardiovascular disease (CVD), but it is not associated with a statistically significantly increased ...

Genetic risks for type 2 diabetes span multiple ethnicities

Feb 09, 2012

A recent large and comprehensive analysis of 50,000 genetic variants across 2,000 genes linked to cardiovascular and metabolic function has identified four genes associated with type 2 diabetes (T2D) and six independent disease-associated ...

Recommended for you

Adrenal sex hormone level may predict heart disease risk

7 hours ago

(HealthDay)—Blood levels of the adrenal sex hormone dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) may predict an increased risk of coronary heart disease (CHD) in elderly men, according to a study ...

Researchers aim to simplify life saving drug

Oct 29, 2014

Heparin, the life saving blood thinner used in major surgeries and treatment of heart diseases, is a complicated drug but a research team from the University of British Columbia has set out to make its use a lot safer by ...

Frequent readmissions, high costs after cardiac arrest

Oct 29, 2014

(HealthDay)—Frequent readmissions and high inpatient costs are seen among older survivors of in-hospital cardiac arrest, according to a study published online Oct. 28 in Circulation: Cardiovascular Quality an ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.