More GI bleeding seen in atrial fibrillation patients on rivaroxaban than warfarin
Patients with atrial fibrillation (AF) experienced more major and non-major clinically relevant GI bleeding when taking rivaroxaban than patients taking warfarin.
As part of the ROCKET AF trial, researchers from multiple institutions, including Harvard Medical School; Mount Sinai Medical Center; Janssen Research & Development; and Bayer HealthCare Pharmaceuticals, randomized 14,264 patients with nonvalvular AF to receive either rivaroxaban or dose-adjusted warfarin.
Post-hoc analysis was performed on all patients while receiving study medication until 2 days after the last dose.
Results showed that GI bleeding events (upper, lower, rectal) occurred more frequently in patients receiving rivaroxaban (n=394) than warfarin (n=290). In addition, major and nonmajor, clinically relevant bleeding occurred more frequently with rivaroxaban use than warfarin use.
However, there were fewer fatal GI bleeds with rivaroxaban and the absolute fatality rate was very low.
This study was presented during CHEST 2012, the annual meeting of the American College of Chest Physicians, held October 20 – 25, in Atlanta, Georgia.
Provided by American College of Chest Physicians
- Stroke risk high when anti-clotting drugs stopped Apr 25, 2012 | not rated yet | 0
- Rivaroxaban has less risk of brain bleeding in patients at high risk for stroke Feb 02, 2012 | not rated yet | 0
- Study shows ability of new agent to prevent strokes in patients with atrial fibrillation Aug 10, 2011 | not rated yet | 0
- New agent to prevent strokes in patients with atrial fibrillation shown in major study Nov 16, 2010 | not rated yet | 0
- New blood thinner may lower chances of clots in high-risk heart patients: FDA May 21, 2012 | not rated yet | 0
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
How does momentum, inertia and drag affect the motion of an object?
2 hours ago How does momentum and inertia affect changes in speed, when considering acceleration from thrust, or from decelleration from drag? Say, for a...
What is Time-Varying Voltage?
3 hours ago In circuits, we have no problem saying that the voltage difference between two point is [itex]\cos(\omega t)[/itex], but what does that actually...
Contextual Relationships Between Momentum, Energy, and Force.
5 hours ago *I apologize in advance for the length of this post, if you wish to reduce reading skip to paragraph 5. Or if you are super lazy, the final...
Barometric pressure and the math behind it. Very interesting, I think.
6 hours ago Hey guys, I was actually researching the life of Edmond Halley and discovered that he discovered the relationship between barometric pressure and the...
Doubts in electrostatics
11 hours ago I have a few questions pertaining to some concepts in electrostatics, I'd be grateful if someone would help me out. 1) When we place a positive...
Work done in moving a charge through an electric field
15 hours ago In electrostatics, when you apply an external force to a charge in an electric field to move it from A to B against the field, why is the force said...
- More from Physics Forums - Classical Physics
More news stories
(HealthDay)—Blood levels of free fatty acids are associated with insulin resistance during young adulthood and cardiovascular risk factors in later adulthood, according to a study published online May 13 ...
Cardiology 12 hours ago | not rated yet | 0 |
An experimental, inexpensive iPhone application transmitted diagnostic heart images faster and more reliably than emailing photo images, according to a research study presented at the American Heart Association's Quality ...
Cardiology 13 hours ago | not rated yet | 0
Extracorporeal membrane oxygenation (ECMO), a procedure traditionally used during cardiac surgeries and in the ICU that functions as an artificial replacement for a patient's heart and lungs, has also been used to resuscitate ...
Cardiology 15 hours ago | not rated yet | 0
Age has little to do with how patients should be treated after suffering a stroke, according to new research from the University of Georgia.
Cardiology 16 hours ago | not rated yet | 0 |
Depressed middle-aged women have almost double the risk of having a stroke, according to research published in Stroke: Journal of the American Heart Association.
Cardiology May 16, 2013 | not rated yet | 0
10 hours ago | not rated yet | 0 |
11 hours ago | 3.7 / 5 (3) | 0 |
8 hours ago | 3.7 / 5 (3) | 0 |
8 hours ago | not rated yet | 0 |
8 hours ago | 5 / 5 (2) | 0 |
Treatment for alcohol use disorders works best if the patient actively understands and incorporates the interventions provided in the clinic. Multiple factors can influence both the type and degree of neurocognitive abnormalities ...
8 hours ago | not rated yet | 0 |