Putting a 'HEX' on muscle regeneration

A complex genetic regulatory network mediates the regeneration of adult skeletal muscles. In this issue of the Journal of Clinical Investigation, researchers at the State University of New York Downstate Medical Center in Brooklyn report that HEXIM1, a protein that regulates gene transcription, is important for skeletal muscle regeneration in mice.

M.A.Q. Saddiqui and colleagues found that HEXIM1 blocks gene expression that is required for muscle regeneration after injury.

Mice with a 50% reduction in HEXIM1 exhibited greater muscle mass and function after injury compared to mice with a normal amount of the gene.

These results indicate that HEXIM1 may be a in degenerative muscle diseases.

More information: HEXIM1 controls satellite cell expansion to regulate skeletal muscle regeneration, Journal of Clinical Investigation, 2012.

Related Stories

'Hulk' protein, Grb10, controls muscle growth

date Aug 30, 2012

Scientists have moved closer toward helping people grow big, strong muscles without needing to hit the weight room. Australian researchers have found that by blocking the function of a protein called Grb10 while mice were ...

Recommended for you

Scientists turn blood into neural cells

date May 21, 2015

Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.