New imaging process provides better picture of tumours
Cancer remains one of the leading causes of death in Europe and the world, and early detection and treatment remains vital in the fight. Researchers in Norway have validated a method of non-invasive imaging that they believe will aid in the identification of aggressive tumours. Their breakthrough provides valuable information about interstitial fluid pressure (IFP) of solid tumours, and their results have been published in Cancer Research.
In the European Union, the long-term aim is the primary prevention of cancer. EU Health Ministers have adopted recommendations for best practice in the early detection of cancer. Regular and systematic examinations can detect the disease early, when it is more responsive to less aggressive treatment. Once detected, the appropriate treatment can be prescribed. It has been shown that these examinations can significantly reduce cancer mortality and improve the quality of life of cancer patients.
The researchers based their research on IFP, which many malignant solid tumours generally develop a higher amount compared to normal tissue. Interstitial fluid, also known as tissue fluid, is the solution surrounding our cells. It provides our cells with nutrition as well as a means of waste disposal.
An average person has approximately 11 litres of this fluid in their body. In tumours however, high pressure is created and this may cause a reduced uptake of chemotherapeutic agents and resistance to radiation therapy. In addition, a high IFP has been found to promote metastatic spread, which is when the cancer 'migrates' to another location in the body.
'Currently, an imaging method for non-invasive assessment of the IFP of tumours is needed to evaluate the potential of IFP as a biomarker for cancer aggressiveness and, hence, to identify patients with cancer who may benefit from particularly aggressive treatment because of highly elevated tumour IFP,' said Einar K. Rofstad, Ph.D., of the department of radiation biology at the Institute for Cancer Research, Norwegian Radium Hospital, Oslo, Norway.
What Rofstad and colleagues did was to test the use of dynamic contrast-enhanced magnetic resonance imaging (MRI) to evaluate the velocity of fluid flow from tumours in human cell lines of cervical carcinoma and melanoma implanted in mice. The researchers had hypothesised that the velocity of fluid flow from tumour tissue into adjacent tissue was determined by the IFP drop at the tumour surface.
Their results indicated that the velocity of the fluid flow at the tumour surface strongly correlated with the magnitude of the tumour IFP, and that dynamic contrast-enhanced MRI with gadolinium diethylene-triamine penta-acetic acid (Gd-DTPA) as a contrast agent can be used to noninvasively measure the fluid-flow velocity.
In addition, primary tumours of mice with metastases had a significantly higher IFP and fluid-flow velocity at the tumour surface compared with the primary tumours of metastasis-free mice, confirming that the development of lymph node metastases strongly correlated to the IFP of the primary tumour and the velocity of fluid flow as measured by Gd-DTPA-based dynamic contrast-enhanced MRI.
'Our findings establish that Gd-DTPA-based dynamic contrast-enhanced MRI can noninvasively visualise tumour IFP,' Rofstad said. 'This reveals the potential for the fluid-flow velocity at the tumour surface determined by this imaging method to serve as a novel general biomarker of tumour aggressiveness.'
Rofstad went on to add that comprehensive prospective clinical investigations in several types of cancer are needed to assess the value of fluid-flow velocity at the tumour surface level as a general biomarker for interstitial hypertension-induced cancer aggressiveness.
Journal reference: Cancer Research
Provided by CORDIS
- Noninvasive measurement enables use of IFP as potential biomarker for tumor aggressiveness Oct 01, 2012 | not rated yet | 0
- Genes associated with aggressive breast cancer Aug 16, 2010 | not rated yet | 0
- New strategy to attack tumor-feeding blood vessels Jun 06, 2011 | not rated yet | 0
- Cancer treatment discovery opens tumours to immune cells May 28, 2012 | not rated yet | 0
- Scientists discover new gene responsible for spread of cancer Mar 29, 2006 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Why is zone 1 in liver more prone to ischemic injury?
May 23, 2013 Hi, Is it because around central vein, there is only deoxygenated blood from the vein where as in the periphery there is hepatic artery. Also why...
How can there be villous adenoma in colon, if there are no villi there
May 22, 2013 As title suggest. Thanks :smile:
How can there be a term called "intestinal metaplasia" of stomach
May 21, 2013 Hello everyone, Ok Stomach's normal epithelium is simple columnar, now in intestinal type of adenocarcinoma of stomach it undergoes "intestinal...
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
- More from Physics Forums - Medical Sciences
More news stories
In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins. In recent years they have emerged as disease biomarkers. miRNA profiles have been used ...
Cancer 23 hours ago | not rated yet | 0
Cancer cells spread and grow by avoiding detection and destruction by the immune system. Stimulation of the immune system can help to eliminate cancer cells; however, there are many factors that cause the immune system to ...
Cancer 23 hours ago | 5 / 5 (1) | 0
Researchers from London's Kingston University have begun a two-year study which could help prolong the lives of people with colorectal tumours.
Cancer May 24, 2013 | 5 / 5 (1) | 0
Transformative research from Western University has identified new hormones in the body which may suppress breast cancer and stimulate the regression of breast tumors.
Cancer May 24, 2013 | 5 / 5 (2) | 0
(Medical Xpress)—Curtin University researchers have found evidence that targeting specific cells in the body can reverse the effects of cancer on the immune system.
Cancer May 24, 2013 | 5 / 5 (4) | 0
Coenzyme Q10 decreases all cause mortality by half, according to the results of a multicentre randomised double blind trial presented today at Heart Failure 2013 congress. It is the first drug to improve heart failure mortality ...
4 hours ago | 5 / 5 (1) | 4
Women at a particular stage in their monthly menstrual cycle may be more vulnerable to some of the psychological side-effects associated with stressful experiences, according to a study from UCL.
23 hours ago | 3.7 / 5 (3) | 4 |
Heart failure accelerates the aging process and brings on early andropausal syndrome (AS), according to research presented today at the Heart Failure Congress 2013. AS, also referred to as male 'menopause', was four times ...
4 hours ago | not rated yet | 1
Two mutations central to the development of infantile myofibromatosis (IM)—a disorder characterized by multiple tumors involving the skin, bone, and soft tissue—may provide new therapeutic targets, according to researchers ...
20 hours ago | 3 / 5 (2) | 0 |
Biological processes are generally based on events at the molecular and cellular level. To understand what happens in the course of infections, diseases or normal bodily functions, scientists would need to ...
23 hours ago | 5 / 5 (5) | 0 |
(AP)—Department of Justice lawyers have again asked a federal appeals court in New York to delay lifting age restrictions and prescription requirements on an emergency contraceptive popularly known as the morning-after ...
4 hours ago | not rated yet | 0