Insulin sensitivity normally highest after breakfast

October 26, 2012
Insulin sensitivity normally highest after breakfast
In healthy people without diabetes, glucose responsiveness tends to be higher after breakfast, which may have implications for the design of closed-loop insulin delivery systems for diabetes patients, according to a study published in the November issue of Diabetes.

(HealthDay)—In healthy people without diabetes, glucose responsiveness tends to be higher after breakfast, which may have implications for the design of closed-loop insulin delivery systems for diabetes patients, according to a study published in the November issue of Diabetes.

To determine whether there is a diurnal pattern of after mixed meals, Ahmed Saad, from the Mayo College of Medicine in Rochester, Minn., and colleagues measured postprandial glucose turnover in 20 healthy individuals without diabetes after mixed meals were ingested for breakfast, lunch, and dinner at 7 a.m., 1 p.m., and 7 p.m., respectively. Physical activity was similar in all individuals and on all days.

The researchers found that, after breakfast, glucose excursion was significantly lower, beta-cell responsiveness to glucose and disposition index was higher, and hepatic insulin extraction was significantly lower compared with other meals. Although meal glucose appearance was similar for all meals, suppression of endogenous tended to be lower and tended to be higher after breakfast (both P < 0.01).

"Our results suggest a diurnal pattern to glucose tolerance in healthy humans, and if present in type 1 diabetes, it will need to be incorporated into systems," Saad and colleagues conclude.

Explore further: Pramlintide improves glucose control in type 1 diabetes

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Pramlintide improves glucose control in type 1 diabetes

July 25, 2012

(HealthDay) -- The addition of pramlintide, an analog of the naturally-occurring β-cell peptide amylin, before meals improves blood glucose control in patients with type 1 diabetes receiving insulin through an external ...

Caloric restriction restores glucose response in diabetes

August 9, 2012

(HealthDay) -- Neuronal responsiveness of the hypothalamus to glucose, critical in the regulation of feeding, can be restored in patients with type 2 diabetes by short-term caloric restriction, according to a study published ...

Sleep apnea tied to insulin resistance in young, lean men

August 29, 2012

(HealthDay)—In healthy, lean, young men, the presence of obstructive sleep apnea (OSA) correlates with insulin resistance and compensatory hyperinsulinemia to maintain normal glucose levels, according to a study published ...

Absolute incretin effect reduced in type 2 diabetes

June 25, 2012

(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase insulin secretion, ...

Recommended for you

Formaldehyde damages proteins, not just DNA

September 29, 2016

The capacity of formaldehyde, a chemical frequently used in manufactured goods such as automotive parts and wood products, to damage DNA, interfere with cell replication and cause cancer inspired new federal regulations this ...

Synthetic 3D-printed material helps bones regrow

September 28, 2016

A cheap and easy to make synthetic bone material has been shown to stimulate new bone growth when implanted in the spines of rats and a monkey's skull, researchers said Wednesday.

Epigenetic clock predicts life expectancy

September 28, 2016

UCLA geneticist Steve Horvath led a team of 65 scientists in seven countries to record age-related changes to human DNA, calculate biological age and estimate a person's lifespan. A higher biological age—regardless of chronological ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.