Insulin sensitivity normally highest after breakfast

Insulin sensitivity normally highest after breakfast
In healthy people without diabetes, glucose responsiveness tends to be higher after breakfast, which may have implications for the design of closed-loop insulin delivery systems for diabetes patients, according to a study published in the November issue of Diabetes.

(HealthDay)—In healthy people without diabetes, glucose responsiveness tends to be higher after breakfast, which may have implications for the design of closed-loop insulin delivery systems for diabetes patients, according to a study published in the November issue of Diabetes.

To determine whether there is a diurnal pattern of after mixed meals, Ahmed Saad, from the Mayo College of Medicine in Rochester, Minn., and colleagues measured postprandial glucose turnover in 20 healthy individuals without diabetes after mixed meals were ingested for breakfast, lunch, and dinner at 7 a.m., 1 p.m., and 7 p.m., respectively. Physical activity was similar in all individuals and on all days.

The researchers found that, after breakfast, glucose excursion was significantly lower, beta-cell responsiveness to glucose and disposition index was higher, and hepatic insulin extraction was significantly lower compared with other meals. Although meal glucose appearance was similar for all meals, suppression of endogenous tended to be lower and tended to be higher after breakfast (both P < 0.01).

"Our results suggest a diurnal pattern to glucose tolerance in healthy humans, and if present in type 1 diabetes, it will need to be incorporated into systems," Saad and colleagues conclude.

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Pramlintide improves glucose control in type 1 diabetes

Jul 25, 2012

(HealthDay) -- The addition of pramlintide, an analog of the naturally-occurring β-cell peptide amylin, before meals improves blood glucose control in patients with type 1 diabetes receiving insulin through ...

Absolute incretin effect reduced in type 2 diabetes

Jun 25, 2012

(HealthDay) -- For patients with type 2 diabetes mellitus (T2DM) the absolute incretin effect is reduced compared with healthy individuals, but its relative importance is increased, particularly in first-phase ...

Recommended for you

New malaria vaccine candidates identified

15 hours ago

Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium fa ...

User comments