Direct link ID'd for sleep deprivation, insulin sensitivity

Direct link ID'd for sleep deprivation, insulin sensitivity
Even short-term sleep restriction results in an insulin-resistant state in adipocytes, according to research published in the Oct. 16 issue of the Annals of Internal Medicine.

(HealthDay)—Even short-term sleep restriction results in an insulin-resistant state in adipocytes, according to research published in the Oct. 16 issue of the Annals of Internal Medicine.

Josiane L. Broussard, Ph.D., of the University of Chicago, and colleagues conducted a randomized, two-period crossover study involving seven healthy adults, aged 18 to 30 years, to evaluate whether sleep restriction (4.5 hours sleep per night) causes reduced insulin sensitivity in subcutaneous fat. The intervention comprised four days of 4.5 hours and four days of 8.5 hours in bed, with calorie intake and physical activity controlled. were collected from subcutaneous fat biopsy samples and were exposed to incremental insulin concentrations after both sleep conditions. The ability of insulin to increase levels of phosphorylated Akt (pAkt) was assessed, and cellular insulin sensitivity was measured based on the insulin concentration for the half-maximal pAkt-Akt ratio.

The researchers found that, during sleep restriction, the insulin concentration for the half-maximal Akt-pAkt was nearly three times higher, and the total area under the receiver operating curve of the pAkt-Akt response was reduced by 30 percent. The impaired cellular insulin sensitivity was paralleled by a reduction in total body insulin sensitivity.

"In conclusion, our finding of a robust alteration in intracellular insulin signaling in a peripheral tissue that is pivotal in regulating energy balance and metabolism identifies a underlying the adverse effect of on ," the authors write.

More information: Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

New study shows that even your fat cells need sleep

Oct 15, 2012

In a study that challenges the long-held notion that the primary function of sleep is to give rest to the brain, researchers have found that not getting enough shut-eye has a harmful impact on fat cells, reducing by 30 percent ...

Insulin sensitivity lower in adults born preterm

Sep 27, 2012

(HealthDay)—Middle-aged adults who were born preterm, even moderately preterm (32 to 36 weeks' gestation), are less insulin sensitive compared with adults who were born at term, according to research published ...

Improving obesity-induced insulin sensitivity

Jun 01, 2012

In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into ...

Recommended for you

How Alzheimer's peptides shut down cellular powerhouses

Aug 29, 2014

The failing in the work of nerve cells: An international team of researchers led by Prof. Dr. Chris Meisinger from the Institute of Biochemistry and Molecular Biology of the University of Freiburg has discovered ...

User comments