Study supports link between obesity and higher incidence of cancer, poorer prognosis
Researchers may have discovered a new explanation as to why obese patients with cancer often have a poorer prognosis compared with those who are lean. The potential explanation is based on data reported in Cancer Research, a journal of the American Association for Cancer Research.
"Studies of the population have clearly established that there is a link between obesity and cancer incidence," said Mikhail Kolonin, Ph.D., associate professor at the Institute of Molecular Medicine at The University of Texas Health Science Center at Houston. "Moreover, for several cancers, obesity is associated with a poorer prognosis."
Kolonin and his colleagues evaluated how obesity promotes cancer progression. "Our earlier studies led us to hypothesize that fat tissue called white adipose tissue, which is the fat tissue that expands in individuals who are obese, is itself directly involved and that it is not just diet and lifestyle that are important," he said.
Their initial results confirmed this hypothesis: In obese and lean mice that ate the same diet, tumors grew much faster in obese mice than they did in lean mice. The researchers also observed that there were far more white adipose tissue cells (called adipose stromal cells) in obese mice than in lean mice and thus turned their focus on the role of these cells.
Detailed analyses indicated cancer induced mobilization of adipose stromal cells into the circulation. Once in the tumors, some of these cells developed into fat cells, while others were incorporated into tumor-associated blood vessels.
Tumor-associated blood vessels support tumor growth by bringing in oxygen and nutrients vital for cancer cell survival and proliferation. Kolonin noted that the ability of adipose stromal cells to contribute to the formation of tumor-associated blood vessels is likely one of the main reasons that the excess of these cells in tumors was associated with increased malignant cell proliferation and tumor growth.
"Our data provide the first in vivo evidence of recruitment of cells from endogenous fat tissue to tumors," said Kolonin. "The fact that these cells are present in tumors is still an emerging concept. We have shown that not only are they present, but they are also functional and affect tumor growth. Identifying the signals that cause these cells to be recruited to tumors and finding ways to block them might provide a new avenue of cancer treatment."
Journal reference: Cancer Research
Provided by American Association for Cancer Research
- Review: inflammation's role in obesity-colorectal cancer link Sep 13, 2012 | not rated yet | 0
- Ovarian cancer cells hijack surrounding tissues to enhance tumor growth Sep 04, 2012 | not rated yet | 0
- Some stem cells can trigger tumors Jun 05, 2012 | not rated yet | 0
- Adipose cells and breast cancer -- a dangerous combination Apr 05, 2011 | not rated yet | 0
- Cancer exploits the body's wound-healing process May 05, 2005 | not rated yet | 0
- Motion perception revisited: High Phi effect challenges established motion perception assumptions Apr 23, 2013 | 3 / 5 (2) | 2
- Anything you can do I can do better: Neuromolecular foundations of the superiority illusion (Update) Apr 02, 2013 | 4.5 / 5 (11) | 5
- The visual system as economist: Neural resource allocation in visual adaptation Mar 30, 2013 | 5 / 5 (2) | 9
- Separate lives: Neuronal and organismal lifespans decoupled Mar 27, 2013 | 4.9 / 5 (8) | 0
- Sizing things up: The evolutionary neurobiology of scale invariance Feb 28, 2013 | 4.8 / 5 (10) | 14
Pressure-volume curve: Elastic Recoil Pressure don't make sense
May 18, 2013 From pressure-volume curve of the lung and chest wall (attached photo), I don't understand why would the elastic recoil pressure of the lung is...
If you became brain-dead, would you want them to pull the plug?
May 17, 2013 I'd want the rest of me to stay alive. Sure it's a lousy way to live but it beats being all-the-way dead. Maybe if I make it 20 years they'll...
MRI bill question
May 15, 2013 Dear PFers, The hospital gave us a $12k bill for one MRI (head with contrast). The people I talked to at the hospital tell me that they do not...
Ratio of Hydrogen of Oxygen in Dessicated Animal Protein
May 13, 2013 As an experiment, for the past few months I've been consuming at least one portion of Jell-O or unflavored Knox gelatin per day. I'm 64, in very...
Alcohol and acetaminophen
May 13, 2013 Edit: sorry for the typo in the title , can't edit I looked around on google quite a bit and it's very hard to find precise information on the...
Marie Curie's leukemia
May 13, 2013 Does anyone know what might be the cause of Marie Curie's cancer
- More from Physics Forums - Medical Sciences
More news stories
The use of a smartphone application significantly improves patients' preparation for a colonoscopy, according to new research presented today at Digestive Disease Week (DDW). The preparation process, which begins days in ...
Cancer 13 hours ago | not rated yet | 0
Research presented at Digestive Disease Week (DDW) explores new methods for managing digestive health through diet and lifestyle.
Cancer 13 hours ago | not rated yet | 1
A ground-breaking advance in colonoscopy technology signals the future of colorectal care, according to research presented today at Digestive Disease Week(DDW). Additional research focuses on optimizing the minimal withdrawal ...
Cancer May 18, 2013 | 5 / 5 (2) | 0
(HealthDay)—Concurrent use of two immune checkpoint antibodies—ipilimumab and nivolumab—may be effective for the treatment of advanced melanoma, according to a proof-of-principal study presented in ...
Cancer May 17, 2013 | not rated yet | 0
(HealthDay)—The risks of metastasis and death associated with cutaneous squamous cell carcinoma (CSCC) are low, but significant, and risk factors for poor outcome include tumor diameter, invasion beyond ...
Cancer May 17, 2013 | not rated yet | 0 |
1 hour ago | not rated yet | 0 |
Gourmands and foodies everywhere have long recognized ginger as a great way to add a little peppery zing to both sweet and savory dishes; now, a study from researchers at Columbia University shows purified components of the ...
1 hour ago | not rated yet | 0
1 hour ago | not rated yet | 0 |
2 hours ago | 5 / 5 (1) | 0 |
2 hours ago | 5 / 5 (1) | 0 |
5 hours ago | not rated yet | 0