Link between vitamin D, mortality not impacted by eGFR

Link between vitamin D, mortality not impacted by eGFR
Adults with low levels of 25-hydroxyvitamin D have increased mortality, regardless of the presence of estimated glomerular filtration rate of <60 ml/min/1.73 m², according to a study published online Oct. 24 in PLoS One.

(HealthDay)—Adults with low levels of 25-hydroxyvitamin D (25[OH]D) have increased mortality, regardless of the presence of estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m², according to a study published online Oct. 24 in PLoS One.

Holly Kramer, M.D., M.P.H., from the Loyola University Medical Center in Maywood, Ill., and colleagues examined all-cause across 25(OH)D levels over an 18-year follow-up period for stratified according to their eGFR. Participants included 1,097 U.S. adults with eGFR <60 ml/min/1.73 m² and 14,002 with an eGFR ≥60 ml/min/1.73 m².

The researchers found that, for adults with eGFR <60 ml/min/1.73 m², the prevalence of 25(OH)D levels <30 ng/mL was 76.5 percent and the prevalence of 25(OH)D levels <20 ng/mL was 35.4 percent. The corresponding prevalences among adults with eGFR ≥60 ml/min/1.73 m² were 70.5 and 30.3 percent. After adjustment for covariables, including comorbid conditions, individuals with 25(OH)D levels <12 ng/mL had significantly higher mortality rates compared to those with levels of 24 to <30 ng/mL, with a rate ratio of 1.41 for those with eGFR <60 ml/min/1.73 m² and 1.32 for those with eGFR ≥60 ml/min/1.73 m². After adjustment for all covariates, mortality rates were fairly similar across all 25(OH)D groups with levels above 20 ng/mL.

"In conclusion, while significantly higher mortality rates are noted with 25(OH)D levels <12 ng/mL, mortality rates are fairly similar across the range of 25(OH)D levels 20 to 40 ng/mL among adults with and without <60 ml/min/1.73 m²," the authors write.

More information: Abstract
Full Text

Related Stories

Can eGFR be a routine preoperative renal function test?

date May 20, 2010

A research team from Japan evaluated the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer. Their study showed that eGFR was as equally ...

Post-transplant, eGFR impacts cardio risk independently

date May 30, 2012

(HealthDay) -- In stable kidney transplant recipients, kidney function, as determined by estimated glomerular filtration rate (eGFR), is independently associated with cardiovascular (CVD) events and death, ...

Recommended for you

Fighting back against superbugs

date 1 hour ago

Antibiotics—and antibiotic resistance—are in the news once again, with announcements by McDonald's and Costco that they will eliminate antibiotics that are important to human medicine from use in the ...

Harnessing the power of microbes as therapeutics

date 2 hours ago

A new report recently released by the American Academy of Microbiology discusses how specific microbes can be modified to enhance their therapeutic potential for treating human diseases such as cancer and antibiotic resistant ...

New genetic link found for alcohol-related liver cirrhosis

date 2 hours ago

In most people, any liver damage that might occur from drinking alcohol is reversible. However, in 25 to 30 percent of alcoholics what begins as accumulation of fat in the liver progresses to inflammation, fibrosis and ultimately ...

Could camel antibodies protect humans from MERS?

date 2 hours ago

Antibodies from dromedary camels protected uninfected mice from Middle East Respiratory Syndrome (MERS), and helped infected mice expunge the disease, according to a study published online March 18th in the ...

Sierra Leone ends anti-Ebola lockdown after three days

date 7 hours ago

Sierra Leoneans were once again allowed to leave their homes Sunday evening after the government announced the end of a three-day nationwide lockdown aimed at preventing a resurgence of the deadly Ebola virus.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.