Link between vitamin D, mortality not impacted by eGFR

Link between vitamin D, mortality not impacted by eGFR
Adults with low levels of 25-hydroxyvitamin D have increased mortality, regardless of the presence of estimated glomerular filtration rate of <60 ml/min/1.73 m², according to a study published online Oct. 24 in PLoS One.

(HealthDay)—Adults with low levels of 25-hydroxyvitamin D (25[OH]D) have increased mortality, regardless of the presence of estimated glomerular filtration rate (eGFR) of <60 ml/min/1.73 m², according to a study published online Oct. 24 in PLoS One.

Holly Kramer, M.D., M.P.H., from the Loyola University Medical Center in Maywood, Ill., and colleagues examined all-cause across 25(OH)D levels over an 18-year follow-up period for stratified according to their eGFR. Participants included 1,097 U.S. adults with eGFR <60 ml/min/1.73 m² and 14,002 with an eGFR ≥60 ml/min/1.73 m².

The researchers found that, for adults with eGFR <60 ml/min/1.73 m², the prevalence of 25(OH)D levels <30 ng/mL was 76.5 percent and the prevalence of 25(OH)D levels <20 ng/mL was 35.4 percent. The corresponding prevalences among adults with eGFR ≥60 ml/min/1.73 m² were 70.5 and 30.3 percent. After adjustment for covariables, including comorbid conditions, individuals with 25(OH)D levels <12 ng/mL had significantly higher mortality rates compared to those with levels of 24 to <30 ng/mL, with a rate ratio of 1.41 for those with eGFR <60 ml/min/1.73 m² and 1.32 for those with eGFR ≥60 ml/min/1.73 m². After adjustment for all covariates, mortality rates were fairly similar across all 25(OH)D groups with levels above 20 ng/mL.

"In conclusion, while significantly higher mortality rates are noted with 25(OH)D levels <12 ng/mL, mortality rates are fairly similar across the range of 25(OH)D levels 20 to 40 ng/mL among adults with and without <60 ml/min/1.73 m²," the authors write.

More information: Abstract
Full Text

add to favorites email to friend print save as pdf

Related Stories

Can eGFR be a routine preoperative renal function test?

May 20, 2010

A research team from Japan evaluated the validity of the estimated glomerular filtration rate (eGFR) as a preoperative renal function parameter in patients with gastric cancer. Their study showed that eGFR was as equally ...

Post-transplant, eGFR impacts cardio risk independently

May 30, 2012

(HealthDay) -- In stable kidney transplant recipients, kidney function, as determined by estimated glomerular filtration rate (eGFR), is independently associated with cardiovascular (CVD) events and death, ...

Recommended for you

Ebola reveals shortcomings of African solidarity

7 hours ago

As Africa's leaders meet in Ethiopia to discuss the Ebola crisis, expectations of firm action will be tempered by criticism over the continent's poor record in the early stages of the epidemic.

Second bird flu case confirmed in Canada

23 hours ago

The husband of a Canadian who was diagnosed earlier this week with bird flu after returning from a trip to China has also tested positive for the virus, health officials said Friday.

What exactly is coronavirus?

Jan 30, 2015

The conflicts in Syria and Iraq are straining public health systems and public health efforts meant to prevent and detect the spread of infectious diseases. This is generating a "perfect storm" of conditions for outbreaks. Among the infections raising concern is Middle East Respiratory Syndrome, caused by a type of coronavirus, which emerged in 2012. ...

Scientists find Ebola virus is mutating

Jan 30, 2015

(Medical Xpress)—Researchers working at Institut Pasteur in France have found that the Ebola virus is mutating "a lot" causing concern in the African countries where the virus has killed over eight thous ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.