Metabolic patterns of propofol, sevoflurane differ in children

Metabolic patterns of propofol, sevoflurane differ in children
For children undergoing routine anesthesia for medically indicated magnetic resonance imaging, the metabolic signature varies with use of sevoflurane and propofol, according to a study published in the November issue of Anesthesiology.

(HealthDay)—For children undergoing routine anesthesia for medically indicated magnetic resonance imaging (MRI), the metabolic signature varies with use of sevoflurane and propofol, according to a study published in the November issue of Anesthesiology.

Zvi Jacob, M.D., from Stony Brook University in New York, and colleagues used proton magnetic resonance spectroscopy to examine the metabolic consequences of in 59 children undergoing MRI with sevoflurane or propofol. The scans were acquired after about 60 minutes of anesthesia. Upon emergence from anesthesia, the children were evaluated using the pediatric anesthesia emergence delirium scale.

The researchers found that the metabolic signature with sevoflurane anesthesia comprised higher concentrations of lactate and glucose compared with anesthesia using propofol. There was a significant and positive correlation between lactate and glucose with performance on emergence delirium scores, and a negative correlation for total creatine and the emergence delirium score.

"Our results demonstrating higher glucose and lactate with sevoflurane in the compared to propofol could reflect greater with sevoflurane resulting in enhanced glutamate-neurotransmitter cycling, increased glycolysis and lactate shuttling from astrocytes to neurons or mitochondrial dysfunction," the authors write. "Further, the association between emergence delirium and lactate suggests that anesthesia-induced enhanced cortical activity in the unconscious state may interfere with rapid return to 'coherent' brain connectivity patterns required for normal cognition upon emergence of anesthesia."

More information: Abstract
Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Children's agitation after surgery may be preventable

Oct 08, 2010

Temporary combativeness after surgery—a complication affecting up to half of anesthetized children—may be preventable with drugs that decrease epinephrine production, according to a Medical College ...

Anesthesia regimen linked to post-orthognathic op pain

Jul 31, 2012

(HealthDay) -- Patients undergoing orthognathic maxillofacial surgery experience more pain postoperatively if they receive anesthesia with propofol and remifentanil versus inhalational agents and longer-acting ...

Hormone treatment eases post-surgery distress in children

Jul 01, 2009

A scary unknown for many children, the prospect of surgery can cause intense preoperative anxiety. While some amount of stress is normal, what many parents do not know is that extreme anxiety before surgery can contribute ...

Cold-air anesthesia reduces pain of laser treatment

Jun 22, 2012

(HealthDay) -- In ablative fractionated carbon-dioxide (CO2) laser treatment for photoaging, cold-air anesthesia used in conjunction with topical anesthesia reduces pain significantly more than topical an ...

Recommended for you

US must respond to global health outbreaks, say bioethicists

5 hours ago

Last summer, West Africa fell into the grip of a deadly outbreak of Ebola that has thus far taken the lives of more than 9,500 people. The fear swept up by the epidemic quickly jumped across the Atlantic and landed in the ...

AbbVie to buy leukemia drugmaker Pharmacyclics for $21B

8 hours ago

AbbVie will spend about $21 billion to buy fellow drugmaker Pharmacyclics in a bid to add another major revenue producer to a product portfolio that already includes the world's top-selling drug, the anti-inflammatory ...

Uganda on defensive over medical 'brain drain' uproar

Mar 03, 2015

Uganda's government on Tuesday hit back at mounting criticism of plans to 'export' over 200 health workers to the Caribbean, insisting it was only seeking to regulate an existing labour market and prevent abuses.

Seth Mnookin on vaccination and public health

Mar 02, 2015

Seth Mnookin, an assistant professor of science writing and associate director of MIT's Graduate Program in Science Writing, is the author of "The Panic Virus: The True Story Behind the Vaccine-Autism Controversy" ...

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.