Mold exposure at home could increase risk for sarcoidosis

October 22, 2012

People who are exposed to mold in their homes could be at an increased risk for sarcoidosis, a chronic inflammatory lung disease.

Researchers from Sweden and Slovenia tested 62 nonsmoking patients with sarcoidosis, 34 of whom had extrapulmonary manifestations (EPM).

Patients were tested for β-glucan, an immune-modulating agent found in fungi, and accompanying inflammatory biomarkers, including interleukin (IL)-6, IL-10, and IL-12.

Serum samples were also obtained from 18 with no pulmonary disease or .

Results showed that levels of IL-6 and IL-12 were higher among subjects with sarcoidosis as compared with controls, and IL-12 was significantly higher among subjects with EPM. There also was a significant relation between β-glucan and mold/fungi levels in the home.

Researchers conclude that the results further support the hypothesis that exposure to fungi is important for the risk of .

This study was presented during CHEST 2012, the annual meeting of the , held October 20 – 25, in Atlanta, Georgia.

Explore further: IL-32 expression upregulated in chronic rhinosinusitis

Related Stories

IL-32 expression upregulated in chronic rhinosinusitis

April 17, 2012

(HealthDay) -- Interleukin-32 (IL-32) mRNA expression is significantly higher in biopsies obtained from patients with chronic rhinosinusitis (CRS), compared to levels found in biopsies obtained from individuals without the ...

Vitamin D analogs modulate immunity in psoriasis

March 9, 2012

(HealthDay) -- Vitamin D3 analogs modulate immunity in human psoriasis, inducing thymic stromal lymphopoietin (TSLP) and cathelicidin, according to a study published online March 2 in the British Journal of Dermatology.

Recommended for you

Cause of inflammation in diabetes identified

November 2, 2016

Inflammation is one of the main reasons why people with diabetes experience heart attacks, strokes, kidney problems and other, related complications. Now, in a surprise finding, researchers at Washington University School ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.