Morphology of bicuspid aortic valve influences outcomes

October 19, 2012
Morphology of bicuspid aortic valve influences outcomes
The morphology of bicuspid aortic valve malformations plays an important role in outcomes, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

(HealthDay)—The morphology of bicuspid aortic valve (BAV) malformations plays an important role in outcomes, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

Christiane Pees, M.D., and Ina Michel-Behnke, Ph.D., from the University Children's Hospital in Vienna, prospectively examined 48 with an isolated, native BAV and 48 matching subjects with tricuspid aortic valves for the morphology and size of the aortic valve, aortic root, sinotubular junction, and and their elasticity indexes.

The researchers found normal-size aortic dimensions in the tricuspid aortic valves, but in the BAVs, the ascending aorta and itself dilated with age and aortic elasticity deteriorated. The stiffness was significantly greater in the BAVs (4.43 ± 1.82 versus 3.43 ± 0.81 in the tricuspid aortic valves). There was a significant inverse decrease in the distensibility indexes in the BAVs (6.57 ± 2.83 versus 7.84 ± 2.04 cm² × dynes−1 × 10−6 and 53.5 ± 26.0 versus 64.3 ± 17.9 kPa−1 × 10−3). Even after correction for congenital valve dysfunction, the anteroposterior-oriented phenotype of BAVs showed significantly stiffer and less distensible elasticity, which was more frequent in the left-right-oriented phenotype.

"In conclusion, the morphology of the BAV seems to play a major role in the outcome of BAV disease, although the left-right phenotype is more prone to congenital valve dysfunction, the anteroposterior phenotype showed worse elasticity quality," the authors write.

Explore further: Study examines risk of aortic complications among patients with common congenital heart valve defect

More information: Abstract
Full Text (subscription or payment may be required)

Related Stories

Three SNPs linked to aortic stenosis in older adults

July 6, 2012

(HealthDay) -- Three single nucleotide polymorphisms (SNPs) are associated with aortic stenosis involving tricuspid aortic valves in older patients, according to a study published in the July 1 issue of The American Journal ...

Recommended for you

Optimism may reduce risk of dying prematurely among women

December 7, 2016

Having an optimistic outlook on life—a general expectation that good things will happen—may help people live longer, according to a new study from Harvard T.H. Chan School of Public Health. The study found that women ...

New discovery at heart of healthy cereals

December 6, 2016

A new discovery at the University of Queensland could help reduce heart disease and boost nutrition security – the access to balanced nourishment - globally.

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.